User profiles for José Vázquez-Prado
José Vázquez-PradoProfessor of Pharmacology Verified email at cinvestav.mx Cited by 3653 |
The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer
Aberrant expression and activity of G proteins and G-protein-coupled receptors (GPCRs)
are frequently associated with tumorigenesis. Deep sequencing studies show that 4.2% of …
are frequently associated with tumorigenesis. Deep sequencing studies show that 4.2% of …
[HTML][HTML] P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration
Polarized cell migration results from the transduction of extra-cellular cues promoting the
activation of Rho GTPases with the intervention of multidomain proteins, including guanine …
activation of Rho GTPases with the intervention of multidomain proteins, including guanine …
[HTML][HTML] Potent activation of RhoA by Gαq and Gq-coupled receptors
H Chikumi, J Vázquez-Prado, JM Servitja… - Journal of Biological …, 2002 - ASBMB
Heterotrimeric G proteins of the G i , G s , and G q family control a wide array of physiological
functions primarily by regulating the activity of key intracellular second messenger-…
functions primarily by regulating the activity of key intracellular second messenger-…
α1-Adrenoceptors: function and phosphorylation
JA Garcı́a-Sáinz, J Vázquez-Prado… - European journal of …, 2000 - Elsevier
This review focuses on α 1 -adrenoceptor phosphorylation and function. Most of what is
currently known is based on studies on the hamster α 1B -adrenoceptor. It is known that agonist …
currently known is based on studies on the hamster α 1B -adrenoceptor. It is known that agonist …
Direct targeting of Gαq and Gα11 oncoproteins in cancer cells
Somatic gain-of-function mutations of GNAQ and GNA11, which encode α subunits of
heterotrimeric Gα q/11 proteins, occur in about 85% of cases of uveal melanoma (UM), the most …
heterotrimeric Gα q/11 proteins, occur in about 85% of cases of uveal melanoma (UM), the most …
mTORC1‐and mTORC2‐interacting proteins keep their multifunctional partners focused
…, L Chávez‐Vargas, J Vázquez‐Prado - IUBMB …, 2011 - Wiley Online Library
The mammalian target of rapamycin, best known as mTOR, is a phylogenetically conserved
serine/threonine kinase that controls life‐defining cellular processes such as growth, …
serine/threonine kinase that controls life‐defining cellular processes such as growth, …
P‐REX2, a novel PI‐3‐kinase sensitive Rac exchange factor
H Rosenfeldt, J Vázquez-Prado, JS Gutkind - FEBS letters, 2004 - Wiley Online Library
We have identified an activator of Rac, P‐REX2, that is structurally related to the exchange
factor PtdIns(3,4,5)‐dependent Rac exchanger (P‐REX1), but exhibits distinct tissue‐specific …
factor PtdIns(3,4,5)‐dependent Rac exchanger (P‐REX1), but exhibits distinct tissue‐specific …
α1-Adrenoceptors: subtypes, signaling, and roles in health and disease
JA Garcı́a-Sáinz, J Vázquez-Prado… - Archives of medical …, 1999 - Elsevier
α 1 -Adrenoceptors mediate some of the main actions of the natural catecholamines, adrenaline,
and noradrenaline. They participate in many essential physiological processes, such as …
and noradrenaline. They participate in many essential physiological processes, such as …
G Protein-coupled Receptor-promoted Trafficking of Gβ1γ2 Leads to AKT Activation at Endosomes via a Mechanism Mediated by Gβ1γ2-Rab11a Interaction
…, T Balla, J Vázquez-Prado… - Molecular biology of …, 2008 - Am Soc Cell Biol
G-protein coupled receptors activate heterotrimeric G proteins at the plasma membrane in
which most of their effectors are intrinsically located or transiently associated as the external …
which most of their effectors are intrinsically located or transiently associated as the external …
Phosphatidylinositol 3, 4, 5-triphosphate-dependent Rac exchanger 1 (P-Rex-1), a guanine nucleotide exchange factor for Rac, mediates angiogenic responses to …
Stromal cell-derived factor-1 (SDF-1/CXCL-12) and vascular endothelial growth factor (VEGF),
which can be secreted by hypoxic tumors, promote the generation of new blood vessels. …
which can be secreted by hypoxic tumors, promote the generation of new blood vessels. …