[HTML][HTML] Cellular uptake of Clostridium difficile toxin B: translocation of the N-terminal catalytic domain into the cytosol of eukaryotic cells

G Pfeifer, J Schirmer, J Leemhuis, C Busch… - Journal of Biological …, 2003 - ASBMB
Clostridium difficile toxin B (269 kDa) is one of the causative agents of antibiotic-associated
diarrhea and pseudomembranous colitis. Toxin B acts in the cytosol of eukaryotic target cells …

[HTML][HTML] The host cell chaperone Hsp90 is essential for translocation of the binary Clostridium botulinum C2 toxin into the cytosol

G Haug, J Leemhuis, D Tiemann, DK Meyer… - Journal of Biological …, 2003 - ASBMB
Clostridium botulinum C2 toxin is the prototype of the binary actin-ADP-ribosylating toxins
and consists of the binding component C2II and the enzyme component C2I. The activated …

[HTML][HTML] The Yersinia pseudotuberculosis cytotoxic necrotizing factor (CNFY) selectively activates RhoA

C Hoffmann, M Pop, J Leemhuis, J Schirmer… - Journal of Biological …, 2004 - ASBMB
The cytotoxic necrotizing factors (CNF)1 and CNF2 from pathogenic Escherichia coli strains
activate RhoA, Rac1, and Cdc42 by deamidation of Gln 63 (RhoA) or Gln 61 (Rac and Cdc42…

Reelin signals through apolipoprotein E receptor 2 and Cdc42 to increase growth cone motility and filopodia formation

J Leemhuis, E Bouché, M Frotscher… - Journal of …, 2010 - Soc Neuroscience
Lipoprotein receptor signaling regulates the positioning and differentiation of postmitotic
neurons during development and modulates neuronal plasticity in the mature brain. Depending …

Genetic dissection of α2-adrenoceptor functions in adrenergic versus nonadrenergic cells

…, M Brede, K Hadamek, M Haubold, J Leemhuis… - Molecular …, 2009 - ASPET
α 2 -Adrenoceptors mediate diverse functions of the sympathetic system and are targets for
the treatment of cardiovascular disease, depression, pain, glaucoma, and sympathetic …

[HTML][HTML] Reelin induces EphB activation

…, M Henkemeyer, T Catchpole, J Leemhuis… - Cell research, 2013 - nature.com
The integration of newborn neurons into functional neuronal networks requires migration of
cells to their final position in the developing brain, the growth and arborization of neuronal …

The protein kinase A inhibitor H89 acts on cell morphology by inhibiting Rho kinase

J Leemhuis, S Boutillier, G Schmidt, DK Meyer - Journal of Pharmacology …, 2002 - ASPET
The small GTPase RhoA can retract cell extensions by acting on two Rho kinases (ROCKs).
Activated protein kinase A (PKA) inhibits RhoA and induces extensions. The isoquinoline …

Cellular Uptake of Clostridium botulinum C2 Toxin:  Membrane Translocation of a Fusion Toxin Requires Unfolding of Its Dihydrofolate Reductase Domain

G Haug, C Wilde, J Leemhuis, DK Meyer, K Aktories… - Biochemistry, 2003 - ACS Publications
The Clostridium botulinum C2 toxin is the prototype of the family of binary actin−ADP-ribosylating
toxins. C2 toxin is composed of two separated nonlinked proteins. The enzyme …

[HTML][HTML] Rho GTPases and phosphoinositide 3-kinase organize formation of branched dendrites

J Leemhuis, S Boutillier, H Barth, TJ Feuerstein… - Journal of Biological …, 2004 - ASBMB
Neurons receive information from other neurons via their dendritic tree. Dendrites and their
branches result from alternating outgrowth and retraction. The Rho GTPases Rac and Cdc42 …

Sympathetic α2-adrenoceptors prevent cardiac hypertrophy and fibrosis in mice at baseline but not after chronic pressure overload

…, A Lother, S Schickinger, J Leemhuis… - Cardiovascular …, 2010 - academic.oup.com
Aims α 2 -Adrenoceptors modulate cardiovascular function by vasoconstriction or dilatation,
by central inhibition of sympathetic activity, or by feedback inhibition of norepinephrine …