The low-density lipoprotein (LDL) receptor plays a central role in mammalian cholesterol
metabolism, clearing lipoproteins which bear apolipoproteins E and B-100 from plasma. …

The cell wall of pathogenic fungi such as Cryptococcus neoformans, provides a formidable
barrier to secrete virulence factors that produce host cell damage. To study secretion of …

The cell wall is essential for viability of fungi and is an effective drug target in pathogens such
as Candida albicans. The contribution of post‐transcriptional gene regulators to cell wall …

Cryptococcus neoformans (Cn) and Cryptococcus gattii (Cg) cause neurological disease and
cross the BBB as free cells or in mononuclear phagocytes via the Trojan horse mechanism…

The trehalose pathway is essential for stress tolerance and virulence in fungi. We investigated
the importance of this pathway for virulence of the pathogenic yeast Cryptococcus gattii …

The polysaccharide β‐1,6‐glucan is a major component of the cell wall of Cryptococcus
neoformans, but its function has not been investigated in this fungal pathogen. We have …

Phospholipase B (Plb1) is secreted by pathogenic fungi and is a proven virulence determinant
in Cryptococcus neoformans. Cell-associated Plb1 is presumptively involved in fungal …

Cryptococcus neoformans survives host temperature and regulates cell wall integrity via a
calcium-dependent phosphatase, calcineurin. However, downstream effectors of C. …

Lipid rafts have been identified in the membranes of mammalian cells, the yeast
Saccharomyces cerevisiae, and the pathogenic fungus Candida albicans. Formed by a lateral …

Proper regulation of metabolism is essential to maximizing fitness of organisms in their
chosen environmental niche. Nitrogen metabolite repression is an example of a regulatory …