[HTML][HTML] Substrate specificities of caspase family proteases

…, JA Mankovich, D Banach, T Ghayur, KD Brady… - Journal of Biological …, 1997 - ASBMB
The caspase family represents a new class of intracellular cysteine proteases with known or
suspected roles in cytokine maturation and apoptosis. These enzymes display a preference …

Crystal structure of the cysteine protease interleukin-1β-converting enzyme: a (p20/p10) 2 homodimer

NPC Walker, RV Talanian, KD Brady, LC Dang… - Cell, 1994 - cell.com
Interleukin-1 f3-converting enzyme (ICE) proteolytically cleaves pro-IL-1 3 to its mature,
active form. The crystal structure at 2.5 A resolution of a recombinant human ICE-tetrapeptide …

[HTML][HTML] Mutations in the cone-rod homeobox gene are associated with the cone-rod dystrophy photoreceptor degeneration

…, S Chen, QL Wang, LM Affatigato, CL Coats, KD Brady… - Neuron, 1997 - cell.com
Crx is a novel paired-like homeodomain protein that is expressed predominantly in retinal
photoreceptors and pinealocytes. Its gene has been mapped to chromosome 19q13.3, the site …

Premorbid prevalence of ADHD and development of secondary ADHD after closed head injury

JP Gerring, KD Brady, A Chen, R Vasa… - Journal of the American …, 1998 - Elsevier
OBJECTIVE: To determine premorbid prevalence of attention-deficit hyperactivity disorder (ADHD)
in children with moderate and severe closed head injury (CHI), to determine …

Performance on measures of'executive function'following pediatric traumatic brain injury

…, JP Gerring, MA Grados, R Vasa, KD Brady… - Brain injury, 2002 - Taylor & Francis
Objective : To investigate the relationships among age at injury, neuroanatomic lesion
location, and measures of executive function (EF) following paediatric traumatic brain injury (TBI). …

Caspases as targets for anti-inflammatory and anti-apoptotic drug discovery

RV Talanian, KD Brady, VL Cryns - Journal of medicinal chemistry, 2000 - ACS Publications
… Phosphonate and sulfonate isosteres are very poor ICE substrates (KD Brady, unpublished
observations) and probably offer no advantage for drug development. In the context of acyl …

A catalytic mechanism for caspase-1 and for bimodal inhibition of caspase-1 by activated aspartic ketones

KD Brady, DA Giegel, C Grinnell, E Lunney… - Bioorganic & medicinal …, 1999 - Elsevier
We have evaluated 619 aspartic ketones with 9 different types of prime-side groups (acyloxymethyl,
aryloxymethyl, arylthiomethyl, alkylthiomethyl, acylamino-oxymethyl, …

Exudative retinal detachment following central and hemicentral retinal vein occlusions

…, LM Jampol, H Schatz, KD Brady - Archives of …, 1990 - jamanetwork.com
• We describe five eyes of five patients that developed an exudative retinal detachment
following a central retinal vein occlusion (including one eye with a hemicentral [hemispheric] …

[HTML][HTML] Stability and oligomeric equilibria of refolded interleukin-1β converting enzyme

…, JA Mankovich, JP Welch, WW Wong, KD Brady - Journal of Biological …, 1996 - ASBMB
We report the preparation and characterization of interleukin-1β converting enzyme (ICE)
refolded from its p20 and p10 protein fragments. Refolded ICE heterodimer (p20p10) was …

Speech and interaction in sound-only communication channels

B Butterworth, RR Hine, KD Brady - 1977 - degruyter.com
… BRIAN BUTTERWORTH, RR HINE, KD BRADY … BRIAN BUTTERWORTH, RR HINE,
KD BRADY … Kathleen Brady and Robin Hine were students in psychology at the …