Using subtype-specific antisera, we were able to identify the recently described alpha subunits
of G12 and G13 in platelet membranes as 43-kDa proteins. Activation of the thromboxane …

Thyrotropin is the primary hormone that, via one heptahelical receptor, regulates thyroid cell
functions such as secretion, specific gene expression, and growth. In human thyroid, …

Receptor-regulated class I phosphoinositide 3-kinases (PI3K) phosphorylate the membrane
lipid phosphatidylinositol (PtdIns)-4,5-P 2 to PtdIns-3,4,5-P 3 . This, in turn, recruits and …

The G protein G o is highly expressed in neurons and mediates effects of a group of rhodopsin-like
receptors that includes the opioid, α 2 -adrenergic, M2 muscarinic, and somatostatin …

The human thyrotropin receptor leads upon activation to the stimulation of phospholipase C
and adenylyl cyclase. It is presently not known whether this bifurcating signaling occurs via …

Regulation of effector functions by muscannic acetylcholine receptor subtypes is mediated by
pertussis toxin-sensitive and-insensitive G proteins. In membranes from human embryonic …

We reported previously that Go-deficient mice develop severe neurological defects that
include hyperalgesia, a generalized tremor, lack of coordination, and a turning syndrome …

Opioids are regarded to act via receptors interacting with heterotrimeric pertussis toxin (PTX)-sensitive
C proteins. In membranes of SH-SY5Y cells, the p-selective agonist [u-Ala2, N-Me-…

Heterotrimeric G proteins of the G i class have been implicated in signaling pathways
regulating growth and metabolism under physiological and pathophysiological conditions. …

We have previously shown that platelet ADP receptors are coupled to G-proteins by measuring
the binding of [35S]guanosine-5′-[gamma-thio]triphosphate ([35S]GTP gamma S) to …