User profiles for K. E. Dineley

Kelly T Dineley

Professor, Department of Neurology, University of Texas Medical Branch
Verified email at utmb.edu
Cited by 8617

Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells

…, ML Nealen, NE Burke, KE Dineley… - Proceedings of the …, 2001 - National Acad Sciences
Materials and Methods Reverse Transcription–PCR. Poly (A) RNA was isolated from tissue
or cultured cells by homogenization in Trizol (Life Technologies, Grand Island, NY) followed …

Zinc inhibition of cellular energy production: implications for mitochondria and neurodegeneration

KE Dineley, TV Votyakova… - Journal of …, 2003 - Wiley Online Library
An increasing body of evidence suggests that high intracellular free zinc promotes neuronal
death by inhibiting cellular energy production. A number of targets have been postulated, …

Induction of neuronal apoptosis by thiol oxidation: putative role of intracellular zinc release

…, AK Stout, KA Hartnett, KE Dineley… - Journal of …, 2000 - Wiley Online Library
The membrane‐permeant oxidizing agent 2,2′‐dithiodipyridine (DTDP) can induce Zn 2+
release from metalloproteins in cell‐free systems. Here, we report that brief exposure to …

Nitric oxide-induced changes in intracellular zinc homeostasis are mediated by metallothionein/thionein

…, KJ Wasserloos, KE Dineley… - … of Physiology-Lung …, 2002 - journals.physiology.org
We hypothesized that metallothionein (MT), a cysteine-rich protein with a strong affinity for
Zn 2+ , plays a role in nitric oxide (NO) signaling events via sequestration or release of Zn 2+ …

Zinc causes loss of membrane potential and elevates reactive oxygen species in rat brain mitochondria

KE Dineley, LL Richards, TV Votyakova, IJ Reynolds - Mitochondrion, 2005 - Elsevier
Emerging evidence suggests that Zn 2+ may impair neuronal metabolism. We examined
how Zn 2+ affects the activity of isolated brain mitochondria fueled with glutamate+malate, …

The relationship between intracellular free iron and cell injury in cultured neurons, astrocytes, and oligodendrocytes

GJ Kress, KE Dineley, IJ Reynolds - Journal of Neuroscience, 2002 - Soc Neuroscience
Iron is an essential element for cells but may also be an important cytotoxin. However, very
little is known about iron transport, redox status, or toxicity specifically inside cells. In this study…

Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles

…, DM Estes, ADT Barrett, KT Dineley… - Journal of …, 2014 - Soc Neuroscience
Recent findings suggest that tau oligomers, which form before neurofibrillary tangles (NFTs),
are the true neurotoxic tau entities in neurodegenerative tauopathies, including Alzheimer's …

[HTML][HTML] Accelerated plaque accumulation, associative learning deficits, and up-regulation of α7 nicotinic receptor protein in transgenic mice co-expressing mutant …

KT Dineley, X Xia, D Bui, JD Sweatt, H Zheng - Journal of Biological …, 2002 - ASBMB
Familial Alzheimer's disease-associated mutations in presenilin 1 or 2 or amyloid precursor
protein result in elevated β-amyloid, β-amyloid accumulation, and plaque formation in the …

Direct visualization of mitochondrial zinc accumulation reveals uniporter‐dependent and‐independent transport mechanisms

LM Malaiyandi, O Vergun, KE Dineley… - Journal of …, 2005 - Wiley Online Library
Current evidence suggests that zinc kills neurons by disrupting energy production, specifically
by inhibiting mitochondrial function. However it is unclear if the inhibitory effect requires …

Simultaneous detection of intracellular free calcium and zinc using fura-2FF and FluoZin-3

MJ Devinney II, IJ Reynolds, KE Dineley - Cell calcium, 2005 - Elsevier
… But in conditions where [Ca 2+ ] i is much higher relative to [Zn 2+ ] i , the binding reaction
will be driven more by relative ion concentrations and much less by K D We showed …