International union of pharmacology. XXXIV. Lysophospholipid receptor nomenclature
… -like (KR Lynch, unpublished observation). There is little, if any, evidence for LPL receptors
in any nonvertebrate species. The IUPHAR nomenclature should be applied to mammalian …
in any nonvertebrate species. The IUPHAR nomenclature should be applied to mammalian …
International union of basic and clinical pharmacology. LXXVIII. Lysophospholipid receptor nomenclature
Lysophospholipids are cell membrane-derived lipids that include both glycerophospholipids
such as lysophosphatidic acid (LPA) and sphingoid lipids such as sphingosine 1-…
such as lysophosphatidic acid (LPA) and sphingoid lipids such as sphingosine 1-…
FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity
V Brinkmann, KR Lynch - Current opinion in immunology, 2002 - Elsevier
The novel immunomodulator FTY720 is remarkably effective in models of transplantation
and autoimmunity. Recent data show that phosphorylated FTY720 is an agonist at four …
and autoimmunity. Recent data show that phosphorylated FTY720 is an agonist at four …
[HTML][HTML] The immune modulator FTY720 targets sphingosine 1-phosphate receptors
…, P Hiestand, CA Foster, M Zollinger, KR Lynch - Journal of Biological …, 2002 - ASBMB
Immunosuppressant drugs such as cyclosporin have allowed widespread organ
transplantation, but their utility remains limited by toxicities, and they are ineffective in chronic …
transplantation, but their utility remains limited by toxicities, and they are ineffective in chronic …
Characterization of the human cysteinyl leukotriene CysLT1 receptor
KR Lynch, GP O'neill, Q Liu, DS Im, N Sawyer… - Nature, 1999 - nature.com
The cysteinyl leukotrienes—leukotriene C 4 (LTC 4 ), leukotriene D 4 (LTD 4 ) and
leukotriene E 4 (LTE 4 )—are important mediators of human bronchial asthma 1 , 2 , 3 ,. …
leukotriene E 4 (LTE 4 )—are important mediators of human bronchial asthma 1 , 2 , 3 ,. …
[HTML][HTML] Characterization of the human cysteinyl leukotriene 2 receptor
…, SR George, GP O'Neill, KM Metters, KR Lynch… - Journal of Biological …, 2000 - ASBMB
The contractile and inflammatory actions of the cysteinyl leukotrienes (CysLTs), LTC 4 , LTD
4 , and LTE 4 , are thought to be mediated through at least two distinct but related CysLT G …
4 , and LTE 4 , are thought to be mediated through at least two distinct but related CysLT G …
Regulation of learning and memory by meningeal immunity: a key role for IL-4
…, KM Quinnies, A Crihfield, KR Lynch… - Journal of Experimental …, 2010 - rupress.org
Proinflammatory cytokines have been shown to impair cognition; consequently, immune
activity in the central nervous system was considered detrimental to cognitive function. …
activity in the central nervous system was considered detrimental to cognitive function. …
[HTML][HTML] Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase.
…, D Zeng, ME Durieux, DD D'angelo, KR Lynch… - Journal of biological …, 1992 - Elsevier
Endothelium-derived relaxing factor (EDRF), identified as nitric oxide (NO), is derived from a
guanidino nitrogen of L-arginine via its metabolism by nitric oxide synthase (NOS). Herein, …
guanidino nitrogen of L-arginine via its metabolism by nitric oxide synthase (NOS). Herein, …
Identification and cloning of three novel human G protein-coupled receptor genes GPR52, ΨGPR53 and GPR55: GPR55 is extensively expressed in human brain
M Sawzdargo, T Nguyen, DK Lee, KR Lynch… - Molecular brain …, 1999 - Elsevier
The G protein-coupled receptor (GPCR) family share a structural motif of seven transmembrane
segments with large numbers of conserved residues in those regions. Here, we report …
segments with large numbers of conserved residues in those regions. Here, we report …
[HTML][HTML] Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor
…, MT Wu, CH Liu, TL Macdonald, KR Lynch… - Journal of Biological …, 2007 - ASBMB
Sphingosine 1-phosphate (S1P), a multifunctional lipid mediator, regulates lymphocyte
trafficking, vascular permeability, and angiogenesis by activation of the S1P 1 receptor. This …
trafficking, vascular permeability, and angiogenesis by activation of the S1P 1 receptor. This …