Intrinsic (innate) and acquired (adaptive) resistance to chemotherapy critically limits the
outcome of cancer treatments. For many years, it was assumed that the interaction of a drug with …

Eventually to understand the integrated function of the cell cycle regulatory network, we must
organize the known interactions in the form of a diagram, map, and/or database. A diagram …

Topoisomerase I (Top1) catalyzes two transesterification reactions: single-strand DNA
cleavage and religation that are normally coupled for the relaxation of DNA supercoiling in …

The tumor growth suppressor WAF1/CIP1 was recently shown to be induced by p53 and to
be a potent inhibitor of cyclin-dependent kinases. In the present studies, we sought to …

We used cDNA microarrays to assess gene expression profiles in 60 human cancer cell
lines used in a drug discovery screen by the National Cancer Institute. Using these data, we …

Since 1990, the National Cancer Institute (NCI) has screened more than 60,000 compounds
against a panel of 60 human cancer cell lines. The 50-percent growth-inhibitory …

In the present study, we report the characterization of the p53 tumor suppressor pathway in
the 60 cell lines of the National Cancer Institute (NCI) anticancer drug screen, as well as …

High-throughput and high-content databases are increasingly important resources in molecular
medicine, systems biology, and pharmacology. However, the information usually resides …

… Pommier, Y., Covey, JM, Kerrigan, D., Mattes, W., Markovits, J., and Kohn, KW Role of DNA
intercalation in the inhibition of purified mouse leukemia (L1210) DNA topoisomerase II by 9-…

This work presents a neutral filter elution method for detecting DNA double strand breaks in
mouse L1210 cells after X-ray. The assay will detect the number of double strand breaks …