Background Interleukin-5 (IL-5) is essential for the formation of eosinophils, which are thought
to have a major role in the pathogenesis of asthma and other allergic diseases. We aimed …

Asthma is a complex chronic inflammatory disease of the airways that involves the activation
of many inflammatory and structural cells, all of which release inflammatory mediators that …

We determined the effect of inhaled corticosteroid, budesonide, on the release of the anti-inflammatory
cytokine, interleukin-10 (IL-10), and of pro-inflammatory cytokines, macrophage …

IgE plays an important role in allergic asthma. We hypothesized that reducing IgE in the
airway mucosa would reduce airway inflammation. Forty-five patients with mild to moderate …

An imbalance between proteases and antiproteases may play a role in emphysema, which is
characterized by increased degradation of extracellular matrix, and in airway remodeling in …

The molecular mechanism for the anti-inflammatory action of theophylline is currently unknown,
but low-dose theophylline is an effective add-on therapy to corticosteroids in controlling …

Epidemiologic evidence suggests a link between morbidity and mortality and levels of particulate
matter in the atmosphere. We studied the inflammatory response to inhalation of diesel …

Oxidative stress contributes to airway inflammation and exhaled hydrogen peroxide (H 2 O
2 ) and nitric oxide (NO) are elevated in asthmatic patients. We determined the …

Asthma is associated with increased expression of inflammatory proteins including cytokines,
enzymes, and adhesion molecules. Induction of many of the genes for these proteins is …

… Correspondence and requests for reprints should be addressed to Professor Kian Fan
Chung, MD, D.Sc., National Heart & Lung Institute, Imperial College London, Dovehouse Street, …