User profiles for K. Kolaja
Kyle KolajaCelgene Verified email at celgene.com Cited by 5908 |
The role of oxidative stress in chemical carcinogenesis.
…, JS Isenberg, S Bachowski, KL Kolaja… - Environmental …, 1998 - ehp.niehs.nih.gov
Oxidative stress results when the balance between the production of reactive oxygen species
(ROS) overrides the antioxidant capability of the target cell; oxidative damage from the …
(ROS) overrides the antioxidant capability of the target cell; oxidative damage from the …
Cardiotoxicity of kinase inhibitors: the prediction and translation of preclinical models to clinical outcomes
T Force, KL Kolaja - Nature reviews Drug discovery, 2011 - nature.com
Targeted therapeutics, particularly those that inhibit the activity of protein kinases that are
mutated and/or overexpressed in cancer, have revolutionized the treatment of some cancers …
mutated and/or overexpressed in cancer, have revolutionized the treatment of some cancers …
Opportunities for use of human iPS cells in predictive toxicology
BD Anson, KL Kolaja, TJ Kamp - Clinical Pharmacology & …, 2011 - Wiley Online Library
Toxicity assessment is a major challenge in cost‐effective drug development, and there is a
great need for better tools to accurately predict adverse drug reactions. Technological …
great need for better tools to accurately predict adverse drug reactions. Technological …
High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents
…, JA Thomson, TJ Kamp, KL Kolaja… - American Journal …, 2011 - journals.physiology.org
… I Kr amplitude is reduced at room temperature, and the current can be difficult to resolve;
therefore, the extracellular K concentration was 140 mM to reverse the normal K + …
therefore, the extracellular K concentration was 140 mM to reverse the normal K + …
Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action
…, L Gong, C Hu, R Idury, MSB Judo, KL Kolaja… - Journal of …, 2005 - Elsevier
Successful drug discovery requires accurate decision making in order to advance the best
candidates from initial lead identification to final approval. Chemogenomics, the use of …
candidates from initial lead identification to final approval. Chemogenomics, the use of …
Estimating the risk of drug-induced proarrhythmia using human induced pluripotent stem cell–derived cardiomyocytes
…, MJ Sanders, E Chiao, KL Kolaja - Toxicological …, 2011 - academic.oup.com
… Ouabain, a positive inotropic agent that blocks the Na + /K + -ATPase and elevates
intracellular Na + and Ca 2+ , increased beat amplitude. Treatment with nifedipine, a blocker of L-…
intracellular Na + and Ca 2+ , increased beat amplitude. Treatment with nifedipine, a blocker of L-…
[HTML][HTML] Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells
… ) also increased upon culture in MM (Figure 1K). To test whether this was associated with a
… Consistent with a 2-fold increase in expression of the SCN5a subunit (Figure 1K), there was …
… Consistent with a 2-fold increase in expression of the SCN5a subunit (Figure 1K), there was …
Induction of cyp1a1 is a nonspecific biomarker of aryl hydrocarbon receptor activation: results of large scale screening of pharmaceuticals and toxicants in vivo and in …
… Assay conditions may also make it difficult for in vitro assays to detect the ability of weak-affinity
ligands to displace TCDD from the receptor given the strong affinity of TCDD (K d values …
ligands to displace TCDD from the receptor given the strong affinity of TCDD (K d values …
Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model
…, R Kemper, ET Chiao, KL Kolaja - toxicological …, 2013 - academic.oup.com
Human induced pluripotent stem cell–derived cardiomyocytes (hiPS-CMs) are capable of
detecting drug-induced clinical arrhythmia, Torsade de Pointes (TdP), and QT prolongation. …
detecting drug-induced clinical arrhythmia, Torsade de Pointes (TdP), and QT prolongation. …
Human stem cell-derived cardiomyocytes in cellular impedance assays: bringing cardiotoxicity screening to the front line
…, SD Lamore, L Guo, CW Scott, KL Kolaja - Cardiovascular …, 2015 - Springer
… The response was to develop new assays and approaches that centered specifically around
one promiscuous K + channel, IKR (hERG), that many compounds inhibit, and in doing so, …
one promiscuous K + channel, IKR (hERG), that many compounds inhibit, and in doing so, …