… to its effect on K+ gradient. These data suggested a role of K+ permeability during MxSO4
… It is suggested that MxSO4 may act as a K+ channel agonist to affect the plasmalemmal Ca+…

… Amrinone was shown to cause inhibition of high-K+-induced contractions without significantly
affecting high-K +-induced Ca 2 + uptake (this study and Meisheri et al., 1980a). This was …

… -K+ depolarization. Diltiazem was roughly equally potent in inhibiting contractions induced
by high-K… Ca++ influx and inhibition of contraction when either 40 mM K+ or 10(-8) M NE was …

… Finally, it was observed that the use of 80 mM K+ as a contractile stimulus inhibited NTG
relaxations in a manner similar to the KCa blockers. Collectively, these data provide strong …

This study describes the in vitro and in vivo characteristics of a guanidine 4-morpholinecarboximidine-N-1-adamantyl-N'-cyclohexyl-hydroc
hloride (U-37883A), as an antagonist of …

We describe the Ca 2+ movements in smooth muscle cells at rest and during activation and
relaxation as deduced from transplasmalemmal Ca 2+ fluxes and contractile responses. The …

… NE) or high-K*-induced contractions of rabbit aorta. Amrinone also inhibited carbachol or
high-K+-… Neither total tissue 4SCa uptake nor the rate of 4SCa uptake induced by 80 mM K ÷ in …

… a potent and selective inhibitor of ATP-sensitive K+ channels (… actions of K+channel openers
in vascular smooth muscle. … glyburide as a vascular K+ antagonist [Meisheri, KD, unpubl. …

The present study describes the preclinical pharmacology of a highly selective 5-HT 1D
receptor agonist PNU-142633. PNU-142633 binds with a Ki of 6 nM at the human 5-HT 1D …

This study investigated nitroglygerin (NTG) relaxations in isolated dog coronary artery in
comparison with other vascular preparations. Under maximal PNU-46619 precontraction, the …