FK506-binding protein (FKBP12) was originally identified as the cytosolic receptor for the
immunosuppressant drugs FK506 and rapamycin. The cellular function of FKBP12, a …

Excitation-contraction coupling in skeletal muscle requires the release of intracellular calcium
ions (Ca 2+ ) through ryanodine receptor (RyR1) channels in the sarcoplasmic reticulum. …

… We also observed coupled gating between RyR2 channels with K + used as the charge
carrier (n=3; with use of 250 mmol/L KCl trans/50 mmol/L KCl cis, data not shown). Dissociation …

Recent research demonstrates a reciprocal relationship between gut microbiota-derived
metabolites and the host in controlling the energy homeostasis in mammals. On the one hand, …

Experimental evidence suggests that nitric oxide (NO) and hydrogen sulfide (H 2 S) signaling
pathways are intimately intertwined, with mutual attenuation or potentiation of biological …

Polysulfides (H 2 S x ) represent a class of reactive sulfur species (RSS) which includes
molecules such as H 2 S 2 , H 2 S 3 , H 2 S 4 , and H 2 S 5, and whose presence and impact in …

Tyrosine kinases indirectly raise intracellular calcium concentration ([Ca 2+ ] i ) by activating
phospholipases that generate inositol 1,4,5-trisphosphate (IP 3 ). IP 3 activates the IP 3 …

Antigen-specific activation of T lymphocytes, via stimulation of the T-cell antigen receptor (TCR)
complex, is marked by a rapid and sustained increase in the concentration of …

The inositol 1,4,5-trisphosphate receptor (IP3R) is a ubiquitously expressed intracellular
calcium (Ca 2+ ) release channel on the endoplasmic reticulum. IP3Rs play key roles in …

… the fact that in various vascular beds the activation of K ATP -channels may lead to different
… inhibitor of K ATP -channels) blocks the H 2 S mediated relaxation, while pinacidil (a K ATP -…