User profiles for K. Schulze-Osthoff

Klaus Schulze-Osthoff

Interfaculty Institute of Biochemistry, University of Tübingen
Verified email at uni-tuebingen.de
Cited by 46235

[HTML][HTML] Many cuts to ruin: a comprehensive update of caspase substrates

U Fischer, RU Jänicke, K Schulze-Osthoff - Cell Death & Differentiation, 2003 - nature.com
Apoptotic cell death is executed by the caspase-mediated cleavage of various vital proteins.
Elucidating the consequences of this endoproteolytic cleavage is crucial for our …

Apoptosis signaling by death receptors

K SchulzeOsthoff, D Ferrari, M Los… - European journal of …, 1998 - Wiley Online Library
… phosphatidylserine to the Correspondence to K. Schulze-Osthoff, Department of Internal
Me- … duced following traumatic injury or exposure to high concentraE-mail: schulze-osthoff@uni-…

Functions of glutathione and glutathione disulfide in immunology and immunopathology

W Dröge, K SchulzeOsthoff, S Mihm… - The FASEB …, 1994 - Wiley Online Library
Even a moderate increase in the cellular cysteine supply elevates the intracellular glutathione
(GSH) and glutathione disulfide (GSSG) levels and potentiates immunological functions of …

[HTML][HTML] Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical …

K Schulze-Osthoff, AC Bakker… - Journal of Biological …, 1992 - Elsevier
Structural mitochondrial damage accompanies the cytotoxic effects of several drugs including
tumor necrosis factor (TNF). Using various inhibitors of mitochondrial electron transport we …

[HTML][HTML] Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal

…, S Baksh, Y Xu, IB Autenrieth, K Schulze-Osthoff… - Cell, 2003 - cell.com
Efficient engulfment of the intact cell corpse is a critical end point of apoptosis, required to
prevent secondary necrosis and inflammation. The presentation of "eat-me" signals on the …

T-helper-1-cell cytokines drive cancer into senescence

…, J Bauer, L Zender, M Schaller, K Schulze-Osthoff… - Nature, 2013 - nature.com
Cancer control by adaptive immunity involves a number of defined death 1 , 2 , 3 , 4 , 5 , 6 ,
7 , 8 and clearance 9 , 10 , 11 mechanisms. However, efficient inhibition of exponential …

Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-kappa B and AP-1.

…, W Dröge, K Schulze-Osthoff - Proceedings of the …, 1994 - National Acad Sciences
The transcription factors NF-kappa B and AP-1 have been implicated in the inducible
expression of a variety of genes involved in responses to oxidative stress and cellular defense …

[HTML][HTML] Small stress proteins as novel regulators of apoptosis: heat shock protein 27 blocks Fas/APO-1-and staurosporine-induced cell death

P Mehlen, K Schulze-Osthoff, AP Arrigo - Journal of Biological Chemistry, 1996 - ASBMB
Small stress protein expression enhances the survival of mammalian cells exposed to
numerous injuries that induce necrotic cell death. The cell surface receptor Fas/APO-1 and its …

PARP is important for genomic stability but dispensable in apoptosis

…, M Jantsch, M Los, K Schulze-Osthoff… - Genes & …, 1997 - genesdev.cshlp.org
Mice lacking the gene encoding poly(ADP-ribosyl) transferase (PARP or ADPRT) display no
phenotypic abnormalities, although aged mice are susceptible to epidermal hyperplasia …

Activation and caspase-mediated inhibition of PARP: a molecular switch between fibroblast necrosis and apoptosis in death receptor signaling

…, Z Herceg, ZQ Wang, K Schulze-Osthoff - Molecular biology of …, 2002 - Am Soc Cell Biol
Death ligands not only induce apoptosis but can also trigger necrosis with distinct biochemical
and morphological features. We recently showed that in L929 cells CD95 ligation induces …