User profiles for K. Schulze-Osthoff
Klaus Schulze-OsthoffInterfaculty Institute of Biochemistry, University of Tübingen Verified email at uni-tuebingen.de Cited by 46235 |
[HTML][HTML] Many cuts to ruin: a comprehensive update of caspase substrates
U Fischer, RU Jänicke, K Schulze-Osthoff - Cell Death & Differentiation, 2003 - nature.com
Apoptotic cell death is executed by the caspase-mediated cleavage of various vital proteins.
Elucidating the consequences of this endoproteolytic cleavage is crucial for our …
Elucidating the consequences of this endoproteolytic cleavage is crucial for our …
Apoptosis signaling by death receptors
K Schulze‐Osthoff, D Ferrari, M Los… - European journal of …, 1998 - Wiley Online Library
… phosphatidylserine to the Correspondence to K. Schulze-Osthoff, Department of Internal
Me- … duced following traumatic injury or exposure to high concentraE-mail: schulze-osthoff@uni-…
Me- … duced following traumatic injury or exposure to high concentraE-mail: schulze-osthoff@uni-…
Functions of glutathione and glutathione disulfide in immunology and immunopathology
W Dröge, K Schulze‐Osthoff, S Mihm… - The FASEB …, 1994 - Wiley Online Library
Even a moderate increase in the cellular cysteine supply elevates the intracellular glutathione
(GSH) and glutathione disulfide (GSSG) levels and potentiates immunological functions of …
(GSH) and glutathione disulfide (GSSG) levels and potentiates immunological functions of …
[HTML][HTML] Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical …
K Schulze-Osthoff, AC Bakker… - Journal of Biological …, 1992 - Elsevier
Structural mitochondrial damage accompanies the cytotoxic effects of several drugs including
tumor necrosis factor (TNF). Using various inhibitors of mitochondrial electron transport we …
tumor necrosis factor (TNF). Using various inhibitors of mitochondrial electron transport we …
[HTML][HTML] Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal
Efficient engulfment of the intact cell corpse is a critical end point of apoptosis, required to
prevent secondary necrosis and inflammation. The presentation of "eat-me" signals on the …
prevent secondary necrosis and inflammation. The presentation of "eat-me" signals on the …
T-helper-1-cell cytokines drive cancer into senescence
Cancer control by adaptive immunity involves a number of defined death 1 , 2 , 3 , 4 , 5 , 6 ,
7 , 8 and clearance 9 , 10 , 11 mechanisms. However, efficient inhibition of exponential …
7 , 8 and clearance 9 , 10 , 11 mechanisms. However, efficient inhibition of exponential …
Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-kappa B and AP-1.
…, W Dröge, K Schulze-Osthoff - Proceedings of the …, 1994 - National Acad Sciences
The transcription factors NF-kappa B and AP-1 have been implicated in the inducible
expression of a variety of genes involved in responses to oxidative stress and cellular defense …
expression of a variety of genes involved in responses to oxidative stress and cellular defense …
[HTML][HTML] Small stress proteins as novel regulators of apoptosis: heat shock protein 27 blocks Fas/APO-1-and staurosporine-induced cell death
P Mehlen, K Schulze-Osthoff, AP Arrigo - Journal of Biological Chemistry, 1996 - ASBMB
Small stress protein expression enhances the survival of mammalian cells exposed to
numerous injuries that induce necrotic cell death. The cell surface receptor Fas/APO-1 and its …
numerous injuries that induce necrotic cell death. The cell surface receptor Fas/APO-1 and its …
PARP is important for genomic stability but dispensable in apoptosis
…, M Jantsch, M Los, K Schulze-Osthoff… - Genes & …, 1997 - genesdev.cshlp.org
Mice lacking the gene encoding poly(ADP-ribosyl) transferase (PARP or ADPRT) display no
phenotypic abnormalities, although aged mice are susceptible to epidermal hyperplasia …
phenotypic abnormalities, although aged mice are susceptible to epidermal hyperplasia …
Activation and caspase-mediated inhibition of PARP: a molecular switch between fibroblast necrosis and apoptosis in death receptor signaling
Death ligands not only induce apoptosis but can also trigger necrosis with distinct biochemical
and morphological features. We recently showed that in L929 cells CD95 ligation induces …
and morphological features. We recently showed that in L929 cells CD95 ligation induces …