Beneficial metabolic adaptations due to endurance exercise training in the fasted state

K Van Proeyen, K Szlufcik, H Nielens… - Journal of applied …, 2011 - journals.physiology.org
Training with limited carbohydrate availability can stimulate adaptations in muscle cells to
facilitate energy production via fat oxidation. Here we investigated the effect of consistent …

Training in the fasted state improves glucose tolerance during fat‐rich diet

K Van Proeyen, K Szlufcik, H Nielens… - The Journal of …, 2010 - Wiley Online Library
A fat‐rich energy‐dense diet is an important cause of insulin resistance. Stimulation of fat
turnover in muscle cells during dietary fat challenge may contribute to maintenance of insulin …

Uncoupled IP3 receptor can function as a Ca2+‐leak channel: cell biological and pathological consequences

K Szlufcik, L Missiaen, JB Parys, G Callewaert… - Biology of the …, 2006 - Wiley Online Library
… A detailed pore structure was first available for Streptomyces lividans KcsA, a homotetrameric
K + channel. Each subunit comprises two TMRs connected by a loop. The linking loop is …

[HTML][HTML] Caspase-3-induced truncation of type 1 inositol trisphosphate receptor accelerates apoptotic cell death and induces inositol trisphosphate-independent …

Z Assefa, G Bultynck, K Szlufcik, NN Kasri… - Journal of Biological …, 2004 - ASBMB
Inositol 1,4,5-trisphosphate receptor-deficient (IP 3 RKO) B-lymphocytes were used to investigate
the functional relevance of type 1 inositol 1,4,5-trisphosphate receptor (IP 3 R1) and its …

Disruption of the Candida albicans TPS2 Gene Encoding Trehalose-6-Phosphate Phosphatase Decreases Infectivity without Affecting Hypha Formation

P Van Dijck, L De Rop, K Szlufcik, E Van Ael… - Infection and …, 2002 - Am Soc Microbiol
Deletion of trehalose-6-phosphate phosphatase, encoded by TPS2, in Saccharomyces
cerevisiae results in accumulation of trehalose-6-phosphate (Tre6P) instead of trehalose under …

Exercise-induced, but not creatine-induced, decrease in intramyocellular lipid content improves insulin sensitivity in rats

M Vaisy, K Szlufcik, K De Bock, BO Eijnde… - The Journal of nutritional …, 2011 - Elsevier
The effect of creatine supplementation, alone or in combination with exercise training, on
insulin sensitivity, intramyocellular lipid content (IMCL) and fatty acid translocase (FAT)/CD36 …

Calcineurin and intracellular Ca2+-release channels: regulation or association?

G Bultynck, E Vermassen, K Szlufcik, P De Smet… - Biochemical and …, 2003 - Elsevier
… The first phase was characterized by a K m in the low micromolar range (between 0.1 and
1 μM), whereas the second phase was characterized by a K m in the high micromolar range (…

Thimerosal stimulates Ca2+ flux through inositol 1,4,5-trisphosphate receptor type 1, but not type 3, via modulation of an isoform-specific Ca2+-dependent …

G Bultynck, K Szlufcik, NN Kasri, Z Assefa… - Biochemical …, 2004 - portlandpress.com
… The free [Ca 2+ ] was calculated using the equation [Ca 2+ ]=K d ·(F−F min )/(F max −F) [28],
with a dissociation constant K d of 864 nM, as determined in the cytosol-like medium at 37 C …

The N-terminal Ca2+-independent calmodulin-binding site on the inositol 1, 4, 5-trisphosphate receptor is responsible for calmodulin inhibition, even though this …

NN Kasri, G Bultynck, J Smyth, K Szlufcik, JB Parys… - Molecular …, 2004 - ASPET
Calmodulin (CaM) is a ubiquitous Ca 2+ -sensor protein that plays an important role in
regulating a large number of Ca 2+ channels, including the inositol 1,4,5-trisphosphate receptor (…

High-fat diet overrules the effects of training on fiber-specific intramyocellular lipid utilization during exercise

K Van Proeyen, K Szlufcik, H Nielens… - Journal of Applied …, 2011 - journals.physiology.org
In this study, we compared the effects of endurance training in the fasted state (F) vs. the fed
state [ample carbohydrate intake (CHO)] on exercise-induced intramyocellular lipid (IMCL) …