User profiles for KURT J. ISSELBACHER
Kurt J IsselbacherDirector Emeritus, Massachusetts General Hospital Cancer Center Verified email at mgh.harvard.edu Cited by 53879 |
Isolation of circulating tumor cells using a microvortex-generating herringbone-chip
Rare circulating tumor cells (CTCs) present in the bloodstream of patients with cancer
provide a potentially accessible source for detection, characterization, and monitoring of …
provide a potentially accessible source for detection, characterization, and monitoring of …
Heterozygous Germ Line hCHK2 Mutations in Li-Fraumeni Syndrome
…, M Lubratovich, SJ Verselis, KJ Isselbacher… - Science, 1999 - science.org
The hCHK2 gene encodes the human homolog of the yeast Cds1 and Rad53 G 2 checkpoint
kinases, whose activation in response to DNA damage prevents cellular entry into mitosis. …
kinases, whose activation in response to DNA damage prevents cellular entry into mitosis. …
Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib
…, KJ Isselbacher, J Settleman… - Proceedings of the …, 2005 - National Acad Sciences
Non-small cell lung cancers (NSCLCs) with activating mutations in the kinase domain of the
epidermal growth factor receptor (EGFR) demonstrate dramatic, but transient, responses to …
epidermal growth factor receptor (EGFR) demonstrate dramatic, but transient, responses to …
Epithelioid cell cultures from rat small intestine. Characterization by morphologic and immunologic criteria.
…, J Wands, RL Trelstad, KJ Isselbacher - The Journal of cell …, 1979 - rupress.org
Rat small intestinal epithelial cell lines have been established in vitro and subcultured serially
for periods up to 6 mo. These cells have an epithelioid morphology, grow as monolayers …
for periods up to 6 mo. These cells have an epithelioid morphology, grow as monolayers …
Glucose transport in isolated brush border membrane from rat small intestine
…, K Nelson, J Perrotto, KJ Isselbacher - Journal of Biological …, 1973 - Elsevier
Uptake of labeled d- and l-glucose has been shown to occur with highly purified brush
border membranes from the epithelial cells of rat small intestine using a Millipore filtration …
border membranes from the epithelial cells of rat small intestine using a Millipore filtration …
Abnormal structure and expression of p53 gene in human hepatocellular carcinoma.
…, KM Galvin, TJ Liang, KJ Isselbacher… - Proceedings of the …, 1990 - National Acad Sciences
There is little information regarding the molecular mechanisms of hepatocarcinogenesis.
We studied the p53 gene at the DNA, RNA, and protein level in seven human hepatocellular …
We studied the p53 gene at the DNA, RNA, and protein level in seven human hepatocellular …
Heterozygous ATM mutations do not contribute to early onset of breast cancer
Ataxia telangiectasia (AT) is a recessive syndrome, including cerebellar degeneration,
immunologic defects and cancer predisposition 1,2 , attributed to mutations in the recently …
immunologic defects and cancer predisposition 1,2 , attributed to mutations in the recently …
[HTML][HTML] Germ-Line BRCA1 Mutations in Jewish and Non-Jewish Women with Early-Onset Breast Cancer
…, RB Duda, KA Mayzel, KJ Isselbacher… - … England Journal of …, 1996 - Mass Medical Soc
Background Mutations in a germ-line allele of the BRCA1 gene contribute to the familial breast
cancer syndrome. However, the prevalence of these mutations is unknown in women with …
cancer syndrome. However, the prevalence of these mutations is unknown in women with …
Increased expression of eukaryotic translation initiation factors eIF-4E and eIF-2 alpha in response to growth induction by c-myc.
…, LD Callanan, KJ Isselbacher… - Proceedings of the …, 1993 - National Acad Sciences
Although activation of c-myc is a critical step in the development of lymphomas and other
tumors, its normal function(s) in cell growth remain obscure because few myc-regulated genes …
tumors, its normal function(s) in cell growth remain obscure because few myc-regulated genes …
Congenital galactosemia, a single enzymatic block in galactose metabolism
KJ Isselbacher, EP Anderson, K Kurahashi, HM Kalckar - Science, 1956 - science.org
68% 18% 10% 4% Vitamin suppl. ement (g/100 lb) Vitamin A conc.(200,000) 4.500 g Vitamin
D conc.(400,000) 3.000 g Alpha-tocopherol 10.215 g Choline chloride 272.400 g Niacin …
D conc.(400,000) 3.000 g Alpha-tocopherol 10.215 g Choline chloride 272.400 g Niacin …