Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants
Rationale: Calmodulin (CaM) mutations are associated with an autosomal dominant
syndrome of ventricular arrhythmia and sudden death that can present with divergent clinical …
syndrome of ventricular arrhythmia and sudden death that can present with divergent clinical …
The emerging role of calmodulin regulation of RyR2 in controlling heart rhythm, the progression of heart failure and the antiarrhythmic action of dantrolene
K Walweel, YW Oo, DR Laver - Clinical and Experimental …, 2017 - Wiley Online Library
Cardiac output and rhythm depend on the release and the take‐up of calcium from the
sarcoplasmic reticulum ( SR ). Excessive diastolic calcium leak from the SR due to dysfunctional …
sarcoplasmic reticulum ( SR ). Excessive diastolic calcium leak from the SR due to dysfunctional …
Essential role of calmodulin in RyR inhibition by dantrolene
YW Oo, N Gomez-Hurtado, K Walweel… - Molecular …, 2015 - ASPET
Dantrolene is the first line therapy of malignant hyperthermia. Animal studies suggest that
dantrolene also protects against heart failure and arrhythmias caused by spontaneous Ca 2+ …
dantrolene also protects against heart failure and arrhythmias caused by spontaneous Ca 2+ …
Ryanodine receptor modification and regulation by intracellular Ca2+ and Mg2+ in healthy and failing human hearts
K Walweel, P Molenaar, MS Imtiaz, A Denniss… - Journal of molecular and …, 2017 - Elsevier
Rationale Heart failure is a multimodal disorder, of which disrupted Ca 2 + homeostasis is a
hallmark. Central to Ca 2 + homeostasis is the major cardiac Ca 2 + release channel – the …
hallmark. Central to Ca 2 + homeostasis is the major cardiac Ca 2 + release channel – the …
Calmodulin inhibition of human RyR2 channels requires phosphorylation of RyR2-S2808 or RyR2-S2814
K Walweel, N Gomez-Hurtado, RT Rebbeck… - Journal of molecular and …, 2019 - Elsevier
Calmodulin (CaM) is a Ca-binding protein that binds to, and can directly inhibit cardiac
ryanodine receptor calcium release channels (RyR2). Animal studies have shown that RyR2 …
ryanodine receptor calcium release channels (RyR2). Animal studies have shown that RyR2 …
Dantrolene inhibition of ryanodine channels (RyR2) in artificial lipid bilayers depends on FKBP12. 6
K Walweel, N Beard, DF van Helden… - Journal of General …, 2023 - rupress.org
Dantrolene is a neutral hydantoin that is clinically used as a skeletal muscle relaxant to
prevent overactivation of the skeletal muscle calcium release channel (RyR1) in response to …
prevent overactivation of the skeletal muscle calcium release channel (RyR1) in response to …
Differences in the regulation of RyR2 from human, sheep, and rat by Ca2+ and Mg2+ in the cytoplasm and in the lumen of the sarcoplasmic reticulum
K Walweel, J Li, P Molenaar, MS Imtiaz… - Journal of General …, 2014 - rupress.org
Regulation of the cardiac ryanodine receptor (RyR2) by intracellular Ca 2+ and Mg 2+ plays
a key role in determining cardiac contraction and rhythmicity, but their role in regulating the …
a key role in determining cardiac contraction and rhythmicity, but their role in regulating the …
[HTML][HTML] Potential of β2AR for added benefit in treating heart failure through a better understanding of signaling
K Walweel, E Cheesman, P Molenaar - Current Opinion in Physiology, 2023 - Elsevier
In human heart adrenaline activates the β 2 -adrenoceptor (β 2 AR) to cause powerful increases
in contractile force and acceleration of contraction. This is explained by tight coupling of …
in contractile force and acceleration of contraction. This is explained by tight coupling of …
[HTML][HTML] Calmodulin mutants linked to catecholaminergic polymorphic ventricular tachycardia fail to inhibit human RyR2 channels
K Walweel, N Gomez-Hurtado, YW Oo… - Journal of the American …, 2017 - jacc.org
… Kafa Walweel … Walweel K., Li J., Molenaar P.et al. : "Differences in the regulation of RyR2
from human, sheep, and rat by Ca2+ and Mg2+ in the cytoplasm and in the lumen of the …
from human, sheep, and rat by Ca2+ and Mg2+ in the cytoplasm and in the lumen of the …
[PDF][PDF] REGULATION OF CALCIUM RELEASE CHANNELS (RyR2) IN HEALTHY AND FAILING HUMAN HEARTS
K Walweel - 2014 - nova.newcastle.edu.au
Cardiac disease is the leading cause of death in Australia with over 50,000 deaths annually,
heart failure (HF) being the most prominent (Tomaselli and Zipes 2004). HF is a complex …
heart failure (HF) being the most prominent (Tomaselli and Zipes 2004). HF is a complex …