User profiles for Karen J. Gregory
 | Karen J GregoryMonash University Verified email at monash.edu Cited by 5702 |
The Concise Guide to PHARMACOLOGY 2021/22: G protein‐coupled receptors
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial
publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key …
publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key …
The Concise Guide to PHARMACOLOGY 2019/20: G protein‐coupled receptors
The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial
publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 …
publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 …
Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator
The excitatory neurotransmitter glutamate induces modulatory actions via the metabotropic
glutamate receptors (mGlus), which are class CG protein–coupled receptors (GPCRs). We …
glutamate receptors (mGlus), which are class CG protein–coupled receptors (GPCRs). We …
Practical strategies and concepts in GPCR allosteric modulator discovery: recent advances with metabotropic glutamate receptors
…, CR Hopkins, TM Bridges, KJ Gregory… - Chemical …, 2016 - ACS Publications
Allosteric modulation of GPCRs has initiated a new era of basic and translational discovery,
filled with therapeutic promise yet fraught with caveats. Allosteric ligands stabilize unique …
filled with therapeutic promise yet fraught with caveats. Allosteric ligands stabilize unique …
[HTML][HTML] A Novel Mechanism of G Protein-coupled Receptor Functional Selectivity: MUSCARINIC PARTIAL AGONIST McN-A-343 AS A BITOPIC ORTHOSTERIC …
Many G protein-coupled receptors (GPCRs) possess allosteric binding sites distinct from the
orthosteric site utilized by their cognate ligands, but most GPCR allosteric modulators …
orthosteric site utilized by their cognate ligands, but most GPCR allosteric modulators …
[HTML][HTML] Identification of orthosteric and allosteric site mutations in M2 muscarinic acetylcholine receptors that contribute to ligand-selective signaling bias
Muscarinic acetylcholine receptors contain at least one allosteric site that is topographically
distinct from the acetylcholine, orthosteric binding site. Although studies have investigated …
distinct from the acetylcholine, orthosteric binding site. Although studies have investigated …
[HTML][HTML] Critical role for the second extracellular loop in the binding of both orthosteric and allosteric G protein-coupled receptor ligands
The second extracellular (E2) loop of G protein-coupled receptors (GPCRs) plays an
essential but poorly understood role in the binding of non-peptidic small molecules. We have …
essential but poorly understood role in the binding of non-peptidic small molecules. We have …
[PDF][PDF] Biased mGlu5-positive allosteric modulators provide in vivo efficacy without potentiating mGlu5 modulation of NMDAR currents
Schizophrenia is associated with disruptions in N-methyl-D-aspartate glutamate receptor
subtype (NMDAR)-mediated excitatory synaptic signaling. The metabotropic glutamate …
subtype (NMDAR)-mediated excitatory synaptic signaling. The metabotropic glutamate …
Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS
…, N Jalan-Sakrikar, KJ Gregory… - Journal of …, 2014 - Soc Neuroscience
Metabotropic glutamate (mGlu) receptors play important roles in regulating CNS function
and are known to function as obligatory dimers. Although recent studies have suggested …
and are known to function as obligatory dimers. Although recent studies have suggested …
Allosteric modulation of muscarinic acetylcholine receptors
KJ Gregory, PM Sexton… - Current …, 2007 - ingentaconnect.com
Muscarinic acetylcholine receptors (mAChRs) are prototypical Family AG protein coupled-receptors.
The five mAChR subtypes are widespread throughout the periphery and the central …
The five mAChR subtypes are widespread throughout the periphery and the central …