Neurons in the lateral habenula (LHb) of rats have efferent projections that terminate in the
substantia nigra pars compacta (SNC) and ventral tegmental area (VTA), where cell bodies of …

The management of seizures in the patient with epilepsy relies heavily on antiepileptic drug
(AED) therapy. Fortunately, for a large percentage of patients, AEDs provide excellent …

Since 1993, the Anticonvulsant Drug Development Program has contributed to the successful
development of nine clinically effective drugs for the symptomatic treatment of epilepsy. …

The childhood epilepsy syndrome of benign familial neonatal convulsions (BFNC) exhibits
the remarkable feature of clinical remission within a few weeks of onset and a favourable …

New strategies for introducing genetically encoded activity indicators into animal models
facilitate the investigation of nervous system function. We have developed the PC::G5-tdT …

Cannabidiol (CBD) is a cannabinoid component of marijuana that has no significant activity
at cannabinoid receptors or psychoactive effects. There is considerable interest in CBD as a …

Purpose: We demonstrate the establishment and characterization of a novel virus infection‐induced
seizure model in C57BL/6 mice. Methods: C57BL/6 mice were infected with Theiler's …

Purpose: To examine the role of innate immunity in a novel viral infection–induced seizure
model. Methods: C57BL/6 mice, mouse strains deficient in interleukin (IL)‐1RI, IL‐6, tumor …

Translation of successful target and compound validation studies into clinically effective
therapies is a major challenge, with potential for costly clinical trial failures. This situation holds …

Cells that can participate in an innate immune response within the central nervous system (CNS)
include infiltrating cells (polymorphonuclear leukocytes [PMNs], macrophages, and …