International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors
…, AP IJzerman, KA Jacobson, KN Klotz… - Pharmacological …, 2001 - ASPET
Four adenosine receptors have been cloned and characterized from several mammalian
species. The receptors are named adenosine A 1 , A 2A , A 2B , and A 3 . The A 2A and A 2B …
species. The receptors are named adenosine A 1 , A 2A , A 2B , and A 3 . The A 2A and A 2B …
Adenosine receptors and their ligands
KN Klotz - Naunyn-Schmiedeberg's archives of pharmacology, 2000 - Springer
The regulatory actions of adenosine are mediated via four subtypes of G protein-coupled
receptors distinguished as A 1 , A 2A , A 2B and A 3 receptors. Their presence on basically …
receptors distinguished as A 1 , A 2A , A 2B and A 3 receptors. Their presence on basically …
8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) — a selective high affinity antagonist radioligand for A1 adenosine receptors
MJ Lohse, KN Klotz, J Lindenborn-Fotinos… - Naunyn-Schmiedeberg's …, 1987 - Springer
The properties of 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) as an antagonist ligand for A
1 adenosine receptors were examined and compared with other radioligands for this …
1 adenosine receptors were examined and compared with other radioligands for this …
Analysis of receptor oligomerization by FRAP microscopy
S Dorsch, KN Klotz, S Engelhardt, MJ Lohse… - Nature …, 2009 - nature.com
Here we describe an approach to investigate di- or oligomerization of transmembrane receptors
in living cells with fluorescence recovery after photobleaching (FRAP). We immobilized …
in living cells with fluorescence recovery after photobleaching (FRAP). We immobilized …
Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell …
…, M Junker, H Kneitz, D Kloor, KN Klotz… - Cancer Immunology …, 2011 - Springer
The ectonucleotidases CD39 and CD73 degrade immune stimulatory ATP to adenosine
that inhibits T and NK cell responses via the A 2A adenosine receptor (ADORA2A). This …
that inhibits T and NK cell responses via the A 2A adenosine receptor (ADORA2A). This …
[HTML][HTML] The small antitumoral immune response modifier imiquimod interacts with adenosine receptor signaling in a TLR7-and TLR8-independent fashion
MP Schön, M Schön, KN Klotz - Journal of investigative dermatology, 2006 - Elsevier
Imiquimod, a small-molecule immune response modifier of the imidazoquinoline family, has
shown profound antitumoral and antiviral efficacy both in vitro and in clinical applications in …
shown profound antitumoral and antiviral efficacy both in vitro and in clinical applications in …
Water-Soluble Phosphate Prodrugs of 1-Propargyl-8-styrylxanthine Derivatives, A2A-Selective Adenosine Receptor Antagonists
…, J Maurinsh, U Reith, F Fülle, KN Klotz… - Journal of medicinal …, 2000 - ACS Publications
Water-soluble prodrugs of potent, A 2A -selective adenosine receptor (AR) antagonists were
prepared. 8-(m-Bromostyryl)-3,7-dimethyl-1-propargylxanthine (BS-DMPX, 11) and the …
prepared. 8-(m-Bromostyryl)-3,7-dimethyl-1-propargylxanthine (BS-DMPX, 11) and the …
[HTML][HTML] Adenosine receptors as mediators of both cell proliferation and cell death of cultured human melanoma cells
Adenosine displays contradictory effects on cell growth: it improves cell proliferation, but it
may also induce apoptosis and impair cell survival. Following the pharmacologic …
may also induce apoptosis and impair cell survival. Following the pharmacologic …
Adenosine A1 receptor-mediated activation of phospholipase C in cultured astrocytes depends on the level of receptor expression
K Biber, KN Klotz, M Berger… - Journal of …, 1997 - Soc Neuroscience
Adenosine A 1 receptors induce an inhibition of adenylyl cyclase via G-proteins of the G i/o
family. In addition, simultaneous stimulation of A 1 receptors and of receptor-mediated …
family. In addition, simultaneous stimulation of A 1 receptors and of receptor-mediated …
[3H] MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A3 adenosine receptors
The lack of a radiolabeled selective A 3 adenosine receptor antagonist is a major drawback
for an adequate characterization of this receptor subtype. This paper describes the …
for an adequate characterization of this receptor subtype. This paper describes the …