Acetaminophen is a widely used over-the-counter drug that causes severe hepatic damage
upon overdose. Cytochrome P450-dependent oxidation of acetaminophen results in the …

This review focuses on the non-statin strategies for the treatment of hyperlipidemias in humans.
Even if statins remain the major hypolipidemic drugs at present, an increasing number of …

Aryl hydrocarbon receptor (AhR) is primarily involved in the transcriptional regulation of
CYP1A enzymes, which are the main catalysts of the metabolic activation or inactivation of …

Cytochrome P450 (P450) monooxygenases are capable of catalyzing metabolism of various
endogenous and exogenous compounds, such as bile acids, fatty acids, retinoids, steroids, …

Most of the experiments studying acetaminophen (APAP) induced hepatotoxicity were
performed using moue as model specie, right because its high sensitivity. While the toxic …

Many undesired side effects or therapeutic failures of drugs are the result of differences or
changes in drug metabolism, primarily depending on the levels and activities of cytochrome …

We developed a powerful gas chromatographic/mass spectrometric method allowing
quantitative analysis of 11 structurally similar cholesterol precursors and plant sterols (squalene, …

Cholesterol biosynthetic and metabolic pathways contain several branching points towards
physiologically active molecules, such as coenzyme Q, vitamin D, glucocorticoid and steroid …

Objectives Valproic acid ( VPA )–induced adverse effects, which are sometimes serious in
children, can be associated with alterations in VPA metabolism. VPA ‐evoked toxicity is …

CYP1A1 and CYP1A2 genes encode members of the cytochrome P450 superfamily of
enzymes primarily involved in xenobiotic and drug metabolism. In this paper we examined the …