Characterization of the P5 subfamily of P-type transport ATPases in mice

PJ Schultheis, TT Hagen, KK O'Toole… - Biochemical and …, 2004 - Elsevier
In mammals, the most poorly understood P-type ATPases are those of the P 5 subfamily. To
begin characterization of the mammalian P 5 -ATPases, BLAST searches of DNA sequence …

Modulation of glycine potency in rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes

…, K Erreger, MR Livesey, KK O'toole… - The Journal of …, 2008 - Wiley Online Library
Heteromeric NMDARs are composed of coagonist glycine‐binding NR1 subunits and
glutamate‐binding NR2 subunits. The majority of functional NMDARs in the mammalian central …

Seizure-induced disinhibition of the HPA axis increases seizure susceptibility

KK O'Toole, A Hooper, S Wakefield, J Maguire - Epilepsy research, 2014 - Elsevier
Stress is the most commonly reported precipitating factor for seizures. The proconvulsant
actions of stress hormones are thought to mediate the effects of stress on seizure susceptibility. …

Compromised GABAergic inhibition contributes to tumor-associated epilepsy

G MacKenzie, KK O'Toole, SJ Moss, J Maguire - Epilepsy research, 2016 - Elsevier
Glioblastoma Multiforme (GBM) is the most common form of primary brain tumor with 30–50%
of patients presenting with epilepsy. These tumor-associated seizures are often resistant to …

A Conserved Tyrosine in the β2Subunit M4 Segment Is a Determinant of γ-Aminobutyric Acid Type A Receptor Sensitivity to Propofol

JE Richardson, PS Garcia, KK O'Toole… - The Journal of the …, 2007 - pubs.asahq.org
Background The gamma-aminobutyric acid type A receptor (GABAA-R) beta subunits are
critical targets for the actions for several intravenous general anesthetics, but the precise …

[HTML][HTML] Discrete M3-M4 intracellular loop subdomains control specific aspects of γ-aminobutyric acid type A receptor function

KK O'Toole, A Jenkins - Journal of Biological Chemistry, 2011 - ASBMB
The GABA type A receptor (GABA A R) is a member of the pentameric ligand gated ion channel
(pLGIC) family that mediates ionotropic neurotransmission. Residues in the intracellular …

[HTML][HTML] HITS: Harnessing a collaborative training network to create case studies that integrate high-throughput, complex datasets into curricula

…, AJ Kleinschmit, P Marsteller, KK O'Toole… - Frontiers in …, 2021 - frontiersin.org
As educators and researchers, we often enjoy enlivening classroom discussions by including
examples of cutting-edge high-throughput (HT) technologies that propelled scientific …

The apparent voltage dependence of GABAA receptor activation and modulation is inversely related to channel open probability

KK O'Toole, A Jenkins - Molecular pharmacology, 2012 - ASPET
The GABA type A receptor (GABA A R) is expressed ubiquitously throughout the brain and
is a target for many therapeutic agents, including general anesthetics and benzodiazepines, …

Emergent literacy in print and electronic contexts: The influence of book type, narration source, and attention

KJ O'Toole, KN Kannass - Journal of Experimental Child Psychology, 2018 - Elsevier
Young children learn from traditional print books, but there has been no direct comparison of
their learning from print books and tablet e-books while controlling for narration source. The …

Effectiveness of an avatar educational application for improving heart failure patients' knowledge and self‐care behaviors: A pragmatic randomized controlled trial

…, C Burdeniuk, K Nesbitt, K O'Toole… - Journal of advanced …, 2020 - Wiley Online Library
Aim To evaluate the effectiveness of education using avatars for improving patients’ heart
failure knowledge and self‐care. Background A lack of knowledge and self‐care contributes to …