The aim of this review is to provide a systematic overview on constitutively active G-protein-coupled
receptors (GPCRs), a rapidly evolving area in signal transduction research. We will …

Method We searched PubMed for pertinent literature on the risk of QTc prolongation and/or
TdP associated with commonly used psychotropic drugs. Results Thioridazine and …

The β 2 -adrenoceptor (β 2 AR) couples to the G-protein G s to activate adenylyl cyclase.
Intriguingly, several studies have demonstrated that the β 2 AR can also interact with G-proteins …

The cyclic undecapeptide, cyclosporin (Cs) H, is a potent inhibitor of FMLP-induced superoxide
anion (O2-) formation in human neutrophils. We studied the effects of CsH in comparison …

The efficiency of interactions between G-protein-coupled receptors (GPCRs) and heterotrimeric
guanine nucleotide-binding proteins (G proteins) is greatly influenced by the absolute …

The interaction of an agonist-bound G-protein-coupled receptor (GPCR) with its cognate G-protein
initiates a sequence of experimentally quantifiable changes in both the GPCR and G-…

The β 2 -adrenoreceptor (β 2 AR) couples to the G-protein G s to mediate adenylyl cyclase
activation. The splice variants of G s α differ by a 15-amino acid insert between the Ras-like …

The aim of our study was to examine the effects of different purine nucleotides [GTP, ITP, and
xanthosine 5′-triphosphate (XTP)] on receptor/G protein coupling. As a model system, we …

Species isoforms of histamine H 2 -, H 3 -, and H 4 -receptors differ in their pharmacological
properties. The study aim was to dissect differences between the human H 1 R (hH 1 R) and …

1. HL-60 human leukemia cells are a widely employed model system for the analysis of
signal transduction processes mediated via regulatory heterotrimeric guanine nucleotide-…