Functional identity of proliferating cell nuclear antigen and a DNA polymerase-δ auxiliary protein

…, CK Tan, M Kostura, MB Mathews, AG So, KM Downey… - Nature, 1987 - nature.com
The mechanism of replication of the simian virus 40 (SV40) genome closely resembles that
of cellular chromosomes, thereby providing an excellent model system for examining the …

A new mammalian DNA polymerase with 3'to 5'exonuclease activity: DNA polymerase δ

JJ Byrnes, KM Downey, VL Black, AG So - Biochemistry, 1976 - ACS Publications
Materials and Methods 3H-Labeled deoxyribonucleoside triphosphates were pur-chased
from New England Nuclear Corp. or Amersham-Searle. Unlabeled deoxyribonucleoside …

Fidelity of mammalian DNA replication and replicative DNA polymerases

…, RD Sabatino, TW Myers, CK Tan, KM Downey… - Biochemistry, 1991 - ACS Publications
Revised Manuscript Received September 12, 1991 abstract: Current models suggest that
two or more DNA polymerases may be required for high-fidelity semiconservative DNA …

The benzylthio-pyrimidine U-31,355, a potent inhibitor of HIV-1 reverse transcriptase

…, L Resnick, ME Busso, AG So, KM Downey… - Biochemical …, 1996 - Elsevier
U-31,355, or 4-amino-2-(benzylthio)-6-chloropyrimidine is an inhibitor of human immunodeficiency
virus type 1 (HIV-1) reverse transcriptase (RT) and possesses anti-HIV activity in HIV-…

Molecular mechanisms of manganese mutagenesis.

WS El-Deiry, KM Downey… - Proceedings of the …, 1984 - National Acad Sciences
The mechanism by which DNA polymerase discriminates between complementary and
noncomplementary nucleotides for insertion into a primer terminus has been investigated. …

Further studies on calf thymus DNA polymerase. delta. purified to homogeneity by a new procedure

MYWT Lee, CK Tan, KM Downey, AG So - Biochemistry, 1984 - ACS Publications
Marietta YW T. Lee, Cheng-Keat Tan, Kathleen M. Downey, and Antero G. So* abstract:
DNA polymerase 5 from calf thymus has been purified to apparent homogeneity by a new …

Degradation of deoxyribonucleic acid by a 1, 10-phenanthroline-copper complex: the role of hydroxyl radicals

BG Que, KM Downey, AG So - Biochemistry, 1980 - ACS Publications
Materials and Methods [3H] TTP was purchased from ICN Pharmaceuticals. 1, 10-Phenanthroline
and 2, 9-dimethyl-1, 10-phenanthroline (neocuproine) were obtained from K & K …

Proliferating cell nuclear antigen promotes DNA synthesis past template lesions by mammalian DNA polymerase δ

…, S Shibutani, CK Tan, KM Downey… - Proceedings of the …, 1997 - National Acad Sciences
Consistent with previous observations, proliferating cell nuclear antigen (PCNA) promotes
DNA synthesis by calf thymus DNA polymerase δ (pol δ) past several chemically defined …

Accelerated master's programs in nursing for non-nurses: An integrative review of students' and faculty's perceptions

KM Downey, ME Asselin - Journal of Professional Nursing, 2015 - Elsevier
Accelerated master's programs in nursing for non-nurses (AMPNNNs) are rapidly increasing
in number. They offer accelerated entry into nursing practice for individuals with a …

Autoantibody to the proliferating cell nuclear antigen neutralizes the activity of the auxiliary protein for DNA polymerase delta

…, K Sullivan, X Li, EM Tan, KM Downey… - Nucleic acids …, 1987 - academic.oup.com
Two murine monoclonal antibodies to the proliferating cell nuclear antigen (PCNA), a rabbit
anti-N-terminal peptide antibody and human autoantibody to PCNA reacted with the …