Interferon alpha (IFNα) has been used in the treatment of several types of cancer for almost
30 years, yet the mechanism (s) responsible for its anti-tumoral action remains unknown. A …

The anthracyclin doxorubicin (DXR) is a major antitumor agent known to cause cellular
damage via a number of mechanisms including free radical formation and inhibition of …

Interferon (IFN) α induces a caspase-dependent apoptosis that is associated with activation
of the proapoptotic Bak and Bax, loss of mitochondrial membrane potential, and release of …

Several recent findings have indicated that the promyelocytic leukemia gene product (PML)
oncogenic domains (PODs) are involved in proteasome-mediated degradation of …

Fbw7 is a ubiquitin-ligase that targets several oncoproteins for proteolysis, but the full range
of Fbw7 substrates is not known. Here we show that by performing quantitative proteomics …

Here, we identified caspase-2, protein kinase C (PKC)δ, and c-Jun NH 2 -terminal kinase (JNK)
as key components of the doxorubicin-induced apoptotic cascade. Using cells stably …

Glucocorticoids are fundamental drugs used in the treatment of lymphoid malignancies with
apoptotic cell death as the hitherto proposed mechanism of action. We have recently shown …

Background and Objectives The mechanism of glucocorticoid-induced apoptosis is not fully
understood and early predictive assays based on apoptotic markers for clinical outcome in …

EBNA-5 is one of the Epstein-Barr virus (EBV)-encoded nuclear proteins required for
immortalization of human B lymphocytes. In the nuclei of EBV-transformed lymphoblastoid cell lines …

Subnuclear distribution of the human herpesvirus-8 (HHV-8)- encoded nuclear protein LNA-1
was analysed at high resolution in body cavity (BC) lymphoma-derived cell lines, in cell …