The mechanisms by which physical forces regulate endothelial cells to determine the
complexities of vascular structure and function are enigmatic 1 , 2 , 3 , 4 , 5 . Studies of sensory …

Changes in membrane tension resulting from membrane stretch represent one of the key
elements in blood flow regulation in vascular smooth muscle. However, the molecular …

Current therapies for common types of cancer such as renal cell cancer are often ineffective
and unspecific, and novel pharmacological targets and approaches are in high demand. …

… MURAKI K, IMAIZUMI Y. A novel function of sphingosine-1-phosphate to activate a non-selective
cation channel in human endothelial cells. J Physiol 2001; 537: 431±441. …

In a screen of potential lipid regulators of transient receptor potential (TRP) channels, we
identified sphingosine-1–phosphate (S1P) as an activator of TRPC5. We explored the …

Piezo1 is a mechanosensitive cation channel with widespread physiological importance;
however, its role in the heart is poorly understood. Cardiac fibroblasts help preserve …

TRPC calcium channels are emerging as a ubiquitous feature of vertebrate cells, but
understanding of them is hampered by limited knowledge of the mechanisms of activation and …

Transient receptor potential ankyrin repeat 1 (TRPA1) forms calcium (Ca 2+ )- and zinc (Zn 2+
)-permeable ion channels that sense noxious substances. Despite the biological and …

The molecular components of the large-conductance Ca 2+ -activated K + channels that are
functionally expressed in mitochondria (mitoK Ca ) in cardiac myocytes have not been …

The concentration of free cytosolic Ca 2+ and the voltage across the plasma membrane are
major determinants of cell function. Ca 2+ -permeable non-selective cationic channels are …