[HTML][HTML] Selective activation of vitamin D receptor by lithocholic acid acetate, a bile acid derivative

R Adachi, Y Honma, H Masuno, K Kawana… - Journal of lipid …, 2005 - ASBMB
The vitamin D receptor (VDR), a member of the nuclear receptor superfamily, mediates the
biological actions of the active form of vitamin D, 1α,25-dihydroxyvitamin D 3 . It regulates …

Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR

K Kawana, T Ikuta, Y Kobayashi, O Gotoh… - Molecular …, 2003 - ASPET
The steroid and xenobiotic receptor (SXR) is an orphan nuclear receptor that plays a key role
in the regulation of xenobiotic response by controlling the expression of drug metabolizing …

Safety and effectiveness of adalimumab in Japanese rheumatoid arthritis patients: postmarketing surveillance report of 7740 patients

…, S Haruna, N Ushida, K Kawana… - Modern …, 2014 - academic.oup.com
Objectives. To confirm the safety and effectiveness of adalimumab and to evaluate the influence
of the concomitant use of methotrexate (MTX). Methods. Postmarketing surveillance of …

Suppression of β-catenin signaling by liver X receptor ligands

S Uno, K Endo, Y Jeong, K Kawana, H Miyachi… - Biochemical …, 2009 - Elsevier
The nuclear receptors liver X receptor (LXR) α and LXRβ serve as oxysterol receptors and
play an important role in the regulation of lipid metabolism. We investigated the potential …

Adalimumab discontinuation in patients with early rheumatoid arthritis who were initially treated with methotrexate alone or in combination with adalimumab: 1 year …

…, H Yamanaka, N Ishiguro, N Miyasaka, K Kawana… - RMD open, 2016 - rmdopen.bmj.com
Objectives To evaluate the impact of discontinuation of adalimumab (ADA) for 1 year in
Japanese patients with early rheumatoid arthritis (RA). Methods This 52-week postmarketing …

Selective allosteric ligand activation of the retinoid X receptor heterodimers of NGFI-B and Nurr1

K Morita, K Kawana, M Sodeyama, I Shimomura… - Biochemical …, 2005 - Elsevier
NGFI-B, an orphan member of the NR4A subfamily of the nuclear receptors, recognizes
specific sequences in the promoters of neuronal target genes as a monomer. Although NGFI-B …

[HTML][HTML] Low disease activity for up to 3 years after adalimumab discontinuation in patients with early rheumatoid arthritis: 2-year results of the HOPEFUL-3 Study

…, N Ishiguro, N Miyasaka, K Kawana… - Arthritis Research & …, 2017 - Springer
Background This study was conducted to evaluate the feasibility of long-term adalimumab (ADA)
discontinuation after achievement of low disease activity (LDA) in Japanese patients …

Enhancement of ligand-dependent vitamin D receptor transactivation by the cardiotonic steroid bufalin

…, M Matsunawa, A Yasui, R Adachi, K Kawana… - Biochemical …, 2005 - Elsevier
Bufalin, a bufadienolide type cardiotonic steroid that is one of the major components of the
toad venom-prepared traditional Chinese medicine called Ch’an Su or Senso, exhibits a …

Long-term safety and effectiveness of adalimumab for the treatment of Japanese patients with rheumatoid arthritis: 3-year results from a postmarketing surveillance of …

M Harigai, T Tsuchiya, K Kawana… - Modern …, 2018 - academic.oup.com
Objectives: To determine the safety and effectiveness of and identify associated factors in
long-term adalimumab (ADA) treatment of Japanese patients with rheumatoid arthritis (RA). …

A single site study to investigate the current prevalence of anti‐hepatitis C virus antibody among substance use disorder patients in Hiroshima—Insufficient testing and …

…, Y Nagaoki, S Shimura, K Kawana… - …, 2023 - Wiley Online Library
Aims Hepatitis C virus (HCV) infection among drug users presents an important public health
problem; however, little recognition and few approaches to address this issue in Japan. …