DL-threo-β-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters
K Shimamoto, B Lebrun, Y Yasuda-Kamatani… - Molecular …, 1998 - ASPET
dl-threo-β-Benzyloxyaspartate (dl-TBOA), a novel derivative ofdl-threo-β-hydroxyaspartate,
was synthesized and examined as an inhibitor of sodium-dependent glutamate/aspartate (…
was synthesized and examined as an inhibitor of sodium-dependent glutamate/aspartate (…
Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter
O Boudker, RM Ryan, D Yernool, K Shimamoto… - Nature, 2007 - nature.com
Secondary transporters are integral membrane proteins that catalyse the movement of
substrate molecules across the lipid bilayer by coupling substrate transport to one or more ion …
substrate molecules across the lipid bilayer by coupling substrate transport to one or more ion …
Molecular pharmacology of glutamate transporters, EAATs and VGLUTs
Y Shigeri, RP Seal, K Shimamoto - Brain research reviews, 2004 - Elsevier
l-Glutamate serves as a major excitatory neurotransmitter in the mammalian central nervous
system (CNS) and is stored in synaptic vesicles by an uptake system that is dependent on …
system (CNS) and is stored in synaptic vesicles by an uptake system that is dependent on …
Characterization of novel L-threo-β-benzyloxyaspartate derivatives, potent blockers of the glutamate transporters
K Shimamoto, R Sakai, K Takaoka, N Yumoto… - Molecular …, 2004 - ASPET
Nontransportable blockers of the glutamate transporters are important tools for investigating
mechanisms of synaptic transmission. DL-threo-β-Benzyloxyaspartate (DL-TBOA) is a …
mechanisms of synaptic transmission. DL-threo-β-Benzyloxyaspartate (DL-TBOA) is a …
Dysiherbaine: A New Neurotoxic Amino Acid from the Micronesian Marine Sponge Dysidea herbacea
…, H Kamiya, M Murata, K Shimamoto - Journal of the American …, 1997 - ACS Publications
A new amino acid, dysiherbaine (1), was isolated from a Micronesian sponge Dysidea herbacea.
The structure was determined by using FABMS, ESIMS, FABMS/CID/MS, and one- and …
The structure was determined by using FABMS, ESIMS, FABMS/CID/MS, and one- and …
Transethnic genome-wide association study provides insights in the genetic architecture and heritability of long QT syndrome
…, A Mazzanti, BM Beckmann, K Shimamoto… - Circulation, 2020 - Am Heart Assoc
Background: Long QT syndrome (LQTS) is a rare genetic disorder and a major preventable
cause of sudden cardiac death in the young. A causal rare genetic variant with large effect …
cause of sudden cardiac death in the young. A causal rare genetic variant with large effect …
Transcriptome-based systematic identification of extracellular matrix proteins
…, T Fukuda, Y Oguri, K Shimamoto… - Proceedings of the …, 2008 - National Acad Sciences
Extracellular matrix (ECM), which provides critical scaffolds for all adhesive cells, regulates
proliferation, differentiation, and apoptosis. Different cell types employ customized ECMs, …
proliferation, differentiation, and apoptosis. Different cell types employ customized ECMs, …
Serum interleukin 6 before and after therapy with tocilizumab is a principal biomarker in patients with rheumatoid arthritis
K Shimamoto, T Ito, Y Ozaki, H Amuro… - The Journal of …, 2013 - jrheum.org
Objective. Biologic treatments including the humanized anti-interleukin 6 (anti-IL-6) receptor
antibody tocilizumab (TCZ) provide therapeutic options for patients with rheumatoid arthritis (…
antibody tocilizumab (TCZ) provide therapeutic options for patients with rheumatoid arthritis (…
Synthesis of four diastereomeric L-2-(carboxycyclopropyl) glycines. Conformationally constrained L-glutamate analogs
K Shimamoto, M Ishida, H Shinozaki… - The Journal of Organic …, 1991 - ACS Publications
Introduction The neurobiological effects that L-glutamate (l-G1u) induces in the mammalian
central nervous system (CNS) are well-documented. L-Glu acts chiefly as an excitatory fThe …
central nervous system (CNS) are well-documented. L-Glu acts chiefly as an excitatory fThe …
[HTML][HTML] Enhancing rare variant interpretation in inherited arrhythmias through quantitative analysis of consortium disease cohorts and population controls
…, S Sharma, MN Sheppard, K Shimamoto… - Genetics in …, 2021 - nature.com
Purpose Stringent variant interpretation guidelines can lead to high rates of variants of
uncertain significance (VUS) for genetically heterogeneous disease like long QT syndrome (LQTS…
uncertain significance (VUS) for genetically heterogeneous disease like long QT syndrome (LQTS…