DL-threo-β-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters

K Shimamoto, B Lebrun, Y Yasuda-Kamatani… - Molecular …, 1998 - ASPET
dl-threo-β-Benzyloxyaspartate (dl-TBOA), a novel derivative ofdl-threo-β-hydroxyaspartate,
was synthesized and examined as an inhibitor of sodium-dependent glutamate/aspartate (…

Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter

O Boudker, RM Ryan, D Yernool, K Shimamoto… - Nature, 2007 - nature.com
Secondary transporters are integral membrane proteins that catalyse the movement of
substrate molecules across the lipid bilayer by coupling substrate transport to one or more ion …

Molecular pharmacology of glutamate transporters, EAATs and VGLUTs

Y Shigeri, RP Seal, K Shimamoto - Brain research reviews, 2004 - Elsevier
l-Glutamate serves as a major excitatory neurotransmitter in the mammalian central nervous
system (CNS) and is stored in synaptic vesicles by an uptake system that is dependent on …

Characterization of novel L-threo-β-benzyloxyaspartate derivatives, potent blockers of the glutamate transporters

K Shimamoto, R Sakai, K Takaoka, N Yumoto… - Molecular …, 2004 - ASPET
Nontransportable blockers of the glutamate transporters are important tools for investigating
mechanisms of synaptic transmission. DL-threo-β-Benzyloxyaspartate (DL-TBOA) is a …

Dysiherbaine:  A New Neurotoxic Amino Acid from the Micronesian Marine Sponge Dysidea herbacea

…, H Kamiya, M Murata, K Shimamoto - Journal of the American …, 1997 - ACS Publications
A new amino acid, dysiherbaine (1), was isolated from a Micronesian sponge Dysidea herbacea.
The structure was determined by using FABMS, ESIMS, FABMS/CID/MS, and one- and …

Transethnic genome-wide association study provides insights in the genetic architecture and heritability of long QT syndrome

…, A Mazzanti, BM Beckmann, K Shimamoto… - Circulation, 2020 - Am Heart Assoc
Background: Long QT syndrome (LQTS) is a rare genetic disorder and a major preventable
cause of sudden cardiac death in the young. A causal rare genetic variant with large effect …

Transcriptome-based systematic identification of extracellular matrix proteins

…, T Fukuda, Y Oguri, K Shimamoto… - Proceedings of the …, 2008 - National Acad Sciences
Extracellular matrix (ECM), which provides critical scaffolds for all adhesive cells, regulates
proliferation, differentiation, and apoptosis. Different cell types employ customized ECMs, …

Serum interleukin 6 before and after therapy with tocilizumab is a principal biomarker in patients with rheumatoid arthritis

K Shimamoto, T Ito, Y Ozaki, H Amuro… - The Journal of …, 2013 - jrheum.org
Objective. Biologic treatments including the humanized anti-interleukin 6 (anti-IL-6) receptor
antibody tocilizumab (TCZ) provide therapeutic options for patients with rheumatoid arthritis (…

Synthesis of four diastereomeric L-2-(carboxycyclopropyl) glycines. Conformationally constrained L-glutamate analogs

K Shimamoto, M Ishida, H Shinozaki… - The Journal of Organic …, 1991 - ACS Publications
Introduction The neurobiological effects that L-glutamate (l-G1u) induces in the mammalian
central nervous system (CNS) are well-documented. L-Glu acts chiefly as an excitatory fThe …

[HTML][HTML] Enhancing rare variant interpretation in inherited arrhythmias through quantitative analysis of consortium disease cohorts and population controls

…, S Sharma, MN Sheppard, K Shimamoto… - Genetics in …, 2021 - nature.com
Purpose Stringent variant interpretation guidelines can lead to high rates of variants of
uncertain significance (VUS) for genetically heterogeneous disease like long QT syndrome (LQTS…