Genomic context and TP53 allele frequency define clinical outcomes in TP53-mutated myelodysplastic syndromes

…, N Pemmaraju, M Konopleva, KA Soltysiak… - Blood …, 2020 - ashpublications.org
TP53 mutations are associated with adverse outcomes and shorter response to hypomethylating
agents (HMAs) in myelodysplastic syndrome (MDS). Limited data have evaluated the …

Impact of the variant allele frequency of ASXL1, DNMT3A, JAK2, TET2, TP53, and NPM1 on the outcomes of patients with newly diagnosed acute myeloid …

…, G Nogueras Gonzalez, K Patel, KA Soltysiak… - Cancer, 2020 - Wiley Online Library
Background The impact of the allelic burden of ASXL1, DNMT3A, JAK2, TET2, and TP53
mutations on survival remains unclear in patients with newly diagnosed acute myeloid …

Phase II study of azacitidine with pembrolizumab in patients with intermediate‐1 or higher‐risk myelodysplastic syndrome

…, SA Pierce, XQ Dong, KA Soltysiak… - British journal of …, 2021 - Wiley Online Library
Programmed cell death protein 1 (PD‐1) and PD‐ligand 1 (PD‐L1) expression is
upregulated in cluster of differentiation 34 (CD34) + bone marrow cells from patients with …

The role of TGFβ in hematopoiesis and myeloid disorders

A Bataller, G Montalban-Bravo, KA Soltysiak… - Leukemia, 2019 - nature.com
The role of transforming growth factor-β (TGFβ) signaling in embryological development and
tissue homeostasis has been thoroughly characterized. Its canonical downstream cascade …

Only SF3B1 mutation involving K700E independently predicts overall survival in myelodysplastic syndromes

…, T Kadia, F Ravandi, G Borthakur, KA Soltysiak… - Cancer, 2021 - Wiley Online Library
Background SF3B1 mutations (SF3B1 mut ) in myelodysplastic syndromes (MDS) frequently
involve codon K700E and have a favorable prognosis. The prognostic effect of non‐K700E …

[HTML][HTML] Hematopoiesis under telomere attrition at the single-cell resolution

…, G Montalban-Bravo, CA Class, KA Soltysiak… - Nature …, 2021 - nature.com
The molecular mechanisms that drive hematopoietic stem cell functional decline under
conditions of telomere shortening are not completely understood. In light of recent advances in …

Transcriptomic analysis implicates necroptosis in disease progression and prognosis in myelodysplastic syndromes

…, K Naqvi, Y Wei, H Yang, KA Soltysiak… - Leukemia, 2020 - nature.com
Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis and
cytopenias due to uncontrolled programmed cell death. The presence of pro-inflammatory …

Selective allosteric enhancement of agonist binding and function at human A3 adenosine receptors by a series of imidazoquinoline derivatives

ZG Gao, SG Kim, KA Soltysiak, N Melman… - Molecular …, 2002 - ASPET
We have identified a series of 1H-imidazo-[4,5-c]quinolines as selective allosteric enhancers
of human A 3 adenosine receptors. Several of these compounds potentiated both the …

The LEukemia Artificial Intelligence Program (LEAP) in chronic myeloid leukemia in chronic phase: A model to improve patient outcomes

…, MB Rios, S Pierce, KA Soltysiak… - American journal of …, 2021 - Wiley Online Library
Extreme gradient boosting methods outperform conventional machine‐learning models. Here,
we have developed the LEukemia Artificial intelligence Program (LEAP) with the extreme …

P2Y6 Nucleotide Receptor Activates PKC to Protect 1321N1 Astrocytoma Cells Against Tumor Necrosis Factor-Induced Apoptosis

SG Kim, ZG Gao, KA Soltysiak, TS Chang… - Cellular and molecular …, 2003 - Springer
We recently reported that the activation by UDP of rat P2Y 6 nucleotide receptors expressed
in 1321N1 astrocytoma cells protected them from TNFα-induced apoptosis by suppressing …