Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor
…, NG Ahn, MK Oskarsson, K Fukasawa, KD Paull… - Science, 1998 - science.org
… This paper is dedicated to the memory of Ken Paull, whose untimely death is a significant
loss to NCI and the cancer research community. The authors thank A. Cline and R. …
loss to NCI and the cancer research community. The authors thank A. Cline and R. …
Oxaliplatin, tetraplatin, cisplatin, and carboplatin: spectrum of activity in drug-resistant cell lines and in the cell lines of the National Cancer Institute's Anticancer Drug …
…, M Alvarez, R Parker, E Reed, K Paull… - Biochemical …, 1996 - Elsevier
The present study was designed to explore the activity of platinum compounds in cisplatinresistant
cell lines, the unselected cell lines of the National Cancer Institute's Anticancer Drug …
cell lines, the unselected cell lines of the National Cancer Institute's Anticancer Drug …
[PDF][PDF] Rhodamine efflux patterns predict P-glycoprotein substrates in the National Cancer Institute drug screen.
JS Lee, K Paull, M Alvarez, C Hose, A Monks… - Molecular …, 1994 - Citeseer
Fifty-eight cell lines in the National Cancer Institute drug screen were analyzed for their
ability to effiux the fluorescent dye rhodamine 123 as a functional assay for P-glycoprotein(Pgp). …
ability to effiux the fluorescent dye rhodamine 123 as a functional assay for P-glycoprotein(Pgp). …
Generation of a drug resistance profile by quantitation of mdr-1/P-glycoprotein in the cell lines of the National Cancer Institute Anticancer Drug Screen.
M Alvarez, K Paull, A Monks, C Hose… - The Journal of …, 1995 - Am Soc Clin Investig
Identifying new chemotherapeutic agents and characterizing mechanisms of resistance may
improve cancer treatment. The Anticancer Drug Screen of the National Cancer Institute uses …
improve cancer treatment. The Anticancer Drug Screen of the National Cancer Institute uses …
Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines
DA Scudiero, RH Shoemaker, KD Paull, A Monks… - Cancer research, 1988 - AACR
We have previously described the application of an automated microculture tetrazolium
assay (MTA) involving dimethyl sulfoxide solubilization of cellular-generated 3-(4,5-…
assay (MTA) involving dimethyl sulfoxide solubilization of cellular-generated 3-(4,5-…
Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines
…, P Skehan, R Shoemaker, K Paull… - JNCI: Journal of the …, 1991 - academic.oup.com
We describe here the development and implementation of a pilot-scale, in vitro, anticancer
drug screen utilizing a panel of 60 human tumor cell lines organized into subpanels …
drug screen utilizing a panel of 60 human tumor cell lines organized into subpanels …
Some practical considerations and applications of the National Cancer Institute in vitro anticancer drug discovery screen
MR Boyd, KD Paull - Drug development research, 1995 - Wiley Online Library
During 1985–1990 the US National Cancer Institute (NCI) phased out its murine leukemia
P388 anticancer drug screening program and developed as the replacement a new in vitro …
P388 anticancer drug screening program and developed as the replacement a new in vitro …
P-glycoprotein substrates and antagonists cluster into two distinct groups
S Scala, N Akhmed, US Rao, K Paull, LB Lan… - Molecular …, 1997 - ASPET
To gather further insight into the interaction between P-glycoprotein (Pgp) and its substrates,
167 compounds were analyzed in multidrug resistant human colon carcinoma cells. These …
167 compounds were analyzed in multidrug resistant human colon carcinoma cells. These …
Protein-linked DNA strand breaks induced by NSC 314622, a novel noncamptothecin topoisomerase I poison
G Kohlhagen, KD Paull, M Cushman, P Nagafuji… - Molecular …, 1998 - ASPET
NSC 314622 was found to have a cytotoxicity profile comparable to the topoisomerase I (top1)
inhibitors camptothecin (CPT) and saintopin in the National Cancer Institute In Vitro …
inhibitors camptothecin (CPT) and saintopin in the National Cancer Institute In Vitro …
An information-intensive approach to the molecular pharmacology of cancer
…, VN Viswanadhan, GS Johnson, RE Wittes, KD Paull - Science, 1997 - science.org
Since 1990, the National Cancer Institute (NCI) has screened more than 60,000 compounds
against a panel of 60 human cancer cell lines. The 50-percent growth-inhibitory …
against a panel of 60 human cancer cell lines. The 50-percent growth-inhibitory …