Polycyclic aromatic hydrocarbons (PAHs) are tobacco carcinogens implicated in the causation
of human lung cancer. Metabolic activation is a key prerequisite for PAHs to cause their …

DNA platination by cisplatin (CDDP) was investigated in peripheral blood mononuclear cells
and ovarian cancer cells using atomic absorption spectroscopy. Plots showing the amount …

The evolving role of mitochondria as a target for many anticancer drugs (eg platinum-based
compounds, alkylating agents and anthracyclines) prompted us to investigate their …

Extent of DNA platination, loss of cell viability, DNA fragmentation, and impairment of cellular
mitochondrial oxygen consumption are measures of drug cytotoxicity. We measured and …

The interactions of Jurkat cells with cisplatin, cis-[Pt( 15 NH 3 ) 2 Cl 2 ](1), are studied using
1 H- 15 N heteronuclear single quantum coherence (HSQC) NMR and inductively coupled …

For Jurkat cells in culture exposed to cisplatin (1), we measured the number of platinum
adducts on DNA and showed that it is proportional to the AUC, the area under the concentration …

In this work, we measured the effects of pharmacological concentrations of cisplatin (cis-diaminedichloroplatinum
II) on mitochondrial function, cell viability, and DNA fragmentation in …

The kinetics of the reactions of glutathione (GSH) with 4-hydroperoxycyclophosphamide (4OOH-CP)
and acrolein, a metabolite of 4OOH-CP, were investigated in a cell-free medium (…

I. The kinetics of the reactions of 4-hydroperoxycyclophosphamide (4OOH-CP) and its
metabolite, acrolein, with glutathione (GSH) were investigated in solution and peripheral blood …

An error was made in determining the spacing between bands shown in Figure 4 (page 1107).
This was due to an incorrect conversion of the gel position to fragment length. The correct …