[HTML][HTML] Targeted disruption of soluble epoxide hydrolase reveals a role in blood pressure regulation
Renal microsomal cytochrome P-450 monooxygenase-dependent metabolism of arachidonic
acid generates a series of regioisomeric epoxyeicosatrienoic acids that can be further …
acid generates a series of regioisomeric epoxyeicosatrienoic acids that can be further …
[HTML][HTML] Adrenomedullin stimulates two signal transduction pathways, cAMP accumulation and Ca2+ mobilization, in bovine aortic endothelial cells (∗)
Y Shimekake, K Nagata, S Ohta, Y Kambayashi… - Journal of Biological …, 1995 - ASBMB
The biological action of adrenomedullin, a novel hypotensive peptide, on bovine aortic
endothelial cells, was examined. The specific binding of adrenomedullin to these cells was …
endothelial cells, was examined. The specific binding of adrenomedullin to these cells was …
Common pathogenic mechanism in development progression of liver injury caused by non-alcoholic or alcoholic steatohepatitis
K Nagata, H Suzuki, S Sakaguchi - The Journal of toxicological …, 2007 - jstage.jst.go.jp
This review showed the common pathogenic mechanism in the development of non-alcoholic
or alcoholic steatohepatitis. In particular, we describe the role of innate immune system …
or alcoholic steatohepatitis. In particular, we describe the role of innate immune system …
Progression of alcoholic and non-alcoholic steatohepatitis: common metabolic aspects of innate immune system and oxidative stress
…, S Takahashi, T Sasaki, T Kumagai, K Nagata - Drug metabolism and …, 2011 - Elsevier
Growing evidence indicates that the innate immune system and oxidative stress caused by
gutderived endotoxins play a key role in alcoholic liver disease (ALD). Intracellular …
gutderived endotoxins play a key role in alcoholic liver disease (ALD). Intracellular …
Role of human hepatocyte nuclear factor 4α in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small …
…, T Matsubara, K Yoshinari, K Nagata… - Drug metabolism and …, 2007 - jstage.jst.go.jp
Hepatocyte nuclear factor 4a (HNF4a) is an important transcription factor in hepatic gene
expression. Here, we have investigated the role of HNF4a in the expression of drug-…
expression. Here, we have investigated the role of HNF4a in the expression of drug-…
[HTML][HTML] Protective role of hydroxysteroid sulfotransferase in lithocholic acid-induced liver toxicity
…, A Tozawa, W Honma, M Shimada, K Nagata… - Journal of Biological …, 2003 - ASBMB
Supplement of 1% lithocholic acid (LCA) in the diet for 5–9 days resulted in elevated levels
of the marker for liver damage aspartate aminotransferase and alkaline phosphatase …
of the marker for liver damage aspartate aminotransferase and alkaline phosphatase …
Involvement of CYP2J2 on the intestinal first-pass metabolism of antihistamine drug, astemizole
S Matsumoto, T Hirama, T Matsubara, K Nagata… - Drug Metabolism and …, 2002 - ASPET
Orally administered astemizole is well absorbed but undergoes an extensive first-pass
metabolism toO-desmethylastemizole. Desmethylastemizole is formed in the human microsomal …
metabolism toO-desmethylastemizole. Desmethylastemizole is formed in the human microsomal …
Cytochrome P450 mediated metabolism of diazepam in human and rat: involvement of human CYP2C in N-demethylation in the substrate concentration-dependent …
T Yasumori, K Nagata, SK Yang, LS Chen… - Pharmacogenetics …, 1993 - journals.lww.com
Metabolism of diazepam (DZP) was studied in vitro to clarify the involvement of different forms
of hepatic cytochrome P450 (CYP) in rats, and humans of Japanese and Caucasian origin…
of hepatic cytochrome P450 (CYP) in rats, and humans of Japanese and Caucasian origin…
A common regulatory region functions bidirectionally in transcriptional activation of the human CYP1A1 and CYP1A2 genes
R Ueda, H Iketaki, K Nagata, S Kimura… - Molecular …, 2006 - ASPET
The human CYP1A1 and CYP1A2 genes on chromosome 15 are orientated head-to-head
and are separated by a 23-kilobase (kb) intergenic spacer region. Thus, the possibility exists …
and are separated by a 23-kilobase (kb) intergenic spacer region. Thus, the possibility exists …
Induction of human CYP2A6 is mediated by the pregnane X receptor with peroxisome proliferator-activated receptor-γ coactivator 1α
…, M Nakajima, E Higashi, R Yoshida, K Nagata… - … of Pharmacology and …, 2006 - ASPET
CYP2A6 plays important roles in the metabolism of nicotine and some clinically used drugs.
Interindividual variability in the CYP2A6 expression level in human liver might be caused by …
Interindividual variability in the CYP2A6 expression level in human liver might be caused by …