Renal microsomal cytochrome P-450 monooxygenase-dependent metabolism of arachidonic
acid generates a series of regioisomeric epoxyeicosatrienoic acids that can be further …

The biological action of adrenomedullin, a novel hypotensive peptide, on bovine aortic
endothelial cells, was examined. The specific binding of adrenomedullin to these cells was …

This review showed the common pathogenic mechanism in the development of non-alcoholic
or alcoholic steatohepatitis. In particular, we describe the role of innate immune system …

Growing evidence indicates that the innate immune system and oxidative stress caused by
gutderived endotoxins play a key role in alcoholic liver disease (ALD). Intracellular …

Hepatocyte nuclear factor 4a (HNF4a) is an important transcription factor in hepatic gene
expression. Here, we have investigated the role of HNF4a in the expression of drug-…

Supplement of 1% lithocholic acid (LCA) in the diet for 5–9 days resulted in elevated levels
of the marker for liver damage aspartate aminotransferase and alkaline phosphatase …

Orally administered astemizole is well absorbed but undergoes an extensive first-pass
metabolism toO-desmethylastemizole. Desmethylastemizole is formed in the human microsomal …

Metabolism of diazepam (DZP) was studied in vitro to clarify the involvement of different forms
of hepatic cytochrome P450 (CYP) in rats, and humans of Japanese and Caucasian origin…

The human CYP1A1 and CYP1A2 genes on chromosome 15 are orientated head-to-head
and are separated by a 23-kilobase (kb) intergenic spacer region. Thus, the possibility exists …

CYP2A6 plays important roles in the metabolism of nicotine and some clinically used drugs.
Interindividual variability in the CYP2A6 expression level in human liver might be caused by …