Background—Tumor necrosis factor-α (TNF-α) and angiotensin II (Ang II) modulate heart
failure in part by provoking the hypertrophic response. Signal transduction pathways of those …

The human retinoblastoma gene (RB1) encodes a protein (Rb) of 105 kilodaltons that can
be phosphorylated. Analysis of Rb metabolism has shown that the protein has a half-life of …

Human neutrophil proteinases (elastase, proteinase-3, and cathepsin-G) are released at
sites of acute inflammation. We hypothesized that these inflammation-associated proteinases …

Neutrophil proteinases released at sites of inflammation can affect tissue function by either
activating or disarming signal transduction mediated by proteinase-activated receptors (PARs)…

Hyperglycaemia is a major contributor to diabetic cardiovascular disease with
hyperglycaemia-induced endothelial dysfunction recognized as the initiating cause. Coagulation …

We evaluated the ability of different trypsin-revealed tethered ligand (TL) sequences of rat
proteinase-activated receptor 2 (rPAR 2 ) and the corresponding soluble TL-derived agonist …

Thrombin is known to signal to cells by cleaving/activating a G–protein–coupled family of
proteinase-activated receptors (PARs). The signaling mechanism involves the proteolytic …

We have shown that proteinase-activated receptor-2 (PAR 2) activation in the airways leads
to allergic sensitization to concomitantly inhaled Ags, thus implicating PAR 2 in the …

Purpose: Myopia is a refractive disorder that degrades vision. It can be treated with atropine,
a muscarinic acetylcholine receptor (mAChR) antagonist, but the mechanism is unknown. …

We proposed that circulating metabolites generated by the intestinal microbiota can affect
vascular function. One such metabolite, indole 3-propionic acid (IPA), can activate the …