User profiles for Kouichi Yoshinari
 | Yoshinari, Kouichi 吉成浩一University of Shizuoka Verified email at u-shizuoka-ken.ac.jp Cited by 4765 |
[PDF][PDF] The phenobarbital response enhancer module in the human bilirubin UDP‐glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR
…, H Kojima, A Ueda, S Kakizaki, K Yoshinari… - …, 2001 - Wiley Online Library
The UDP‐glucuronosyltransferase, UGT1A1, is the critical enzyme responsible for detoxification
of the potentially neurotoxic bilirubin by conjugating it with glucuronic acid. For decades, …
of the potentially neurotoxic bilirubin by conjugating it with glucuronic acid. For decades, …
Identification of the nuclear receptor CAR: HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital
K Yoshinari, K Kobayashi, R Moore, T Kawamoto… - FEBS …, 2003 - Wiley Online Library
The nuclear receptor CAR, a phenobarbital (PB)‐responsive transcription factor, translocates
into the nucleus of hepatocytes after PB induction. In non‐induced mice, CAR forms a …
into the nucleus of hepatocytes after PB induction. In non‐induced mice, CAR forms a …
Transcriptional regulation of human UGT1A1 gene expression: activated glucocorticoid receptor enhances constitutive androstane receptor/pregnane X receptor …
J Sugatani, S Nishitani, K Yamakawa, K Yoshinari… - Molecular …, 2005 - ASPET
UDP-glucuronosyltransferase (UGT) 1A1 glucuronidates endogenous metabolites, such as
bilirubin, and exogenous substances, and plays a critical role in their detoxification and …
bilirubin, and exogenous substances, and plays a critical role in their detoxification and …
Role of nuclear receptors PXR and CAR in xenobiotic-induced hepatocyte proliferation and chemical carcinogenesis
K Yoshinari - Biological and Pharmaceutical Bulletin, 2019 - jstage.jst.go.jp
Nuclear receptors pregnane X receptor (PXR) and constitutive active/androstane receptor (CAR)
are xenobiotic-responsible transcriptional factors that belong to the same subfamily and …
are xenobiotic-responsible transcriptional factors that belong to the same subfamily and …
Role of human hepatocyte nuclear factor 4α in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small …
Y Kamiyama, T Matsubara, K Yoshinari… - Drug metabolism and …, 2007 - jstage.jst.go.jp
Hepatocyte nuclear factor 4a (HNF4a) is an important transcription factor in hepatic gene
expression. Here, we have investigated the role of HNF4a in the expression of drug-…
expression. Here, we have investigated the role of HNF4a in the expression of drug-…
Crystal structure‐based studies of cytosolic sulfotransferase
K Yoshinari, EV Petrotchenko… - … of biochemical and …, 2001 - Wiley Online Library
Sulfation is a widely observed biological reaction conserved from bacterium to human that
plays a key role in various biological processes such as growth, development, and defense …
plays a key role in various biological processes such as growth, development, and defense …
Profiling of bisphenol A and eight of its analogues on transcriptional activity via human nuclear receptors
…, S Kitamura, N Uramaru, K Sugihara, K Yoshinari - Toxicology, 2019 - Elsevier
Several bisphenol A (BPA) analogues have been detected in environmental samples,
foodstuffs, and/or human biological samples, and there is concern regarding their potential …
foodstuffs, and/or human biological samples, and there is concern regarding their potential …
Constitutive androstane receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5′-flanking region
K Yoshinari, N Yoda, T Toriyabe, Y Yamazoe - Biochemical pharmacology, 2010 - Elsevier
Phenobarbital has long been known to increase cellular levels of CYP1A1 and CYP1A2
possibly through a pathway(s) independent of aryl hydrocarbon receptor. We have investigated …
possibly through a pathway(s) independent of aryl hydrocarbon receptor. We have investigated …
The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics
…, K Yamakawa, E Tonda, S Nishitani, K Yoshinari… - Biochemical …, 2004 - Elsevier
We identified the UDP-glucuronosyltransferase (UGT) 1A1 5′-upstream region that confers
UGT1A1 induction by various agents, including flavonoids, on a luciferase reporter gene …
UGT1A1 induction by various agents, including flavonoids, on a luciferase reporter gene …
Fibroblast growth factor 19 treatment ameliorates disruption of hepatic lipid metabolism in farnesoid X receptor (Fxr)-null mice
…, Y Sakaida, H Matsuzawa, K Yoshinari… - Biological and …, 2011 - jstage.jst.go.jp
Analysis Fxr-null mice18) and wild-type mice were housed under a standard 12-h light–dark
cycle (9 am—9 pm). Before beginning the experiments, the mice were fed standard rodent …
cycle (9 am—9 pm). Before beginning the experiments, the mice were fed standard rodent …