The experimental conditions that affect equilibrium solubility values measured by the
classical saturation shake-flask method have been examined, using hydrochlorothiazide as a …

The pK a values of 25 structurally diverse drug compounds including mono-, di- and tri-protic
molecules were determined by a recently developed multi-wavelength spectrophotometric …

The goal of this study was to develop a quick, reliable, and cost-effective permeability model
for predicting transdermal penetration of compounds. The Parallel Artificial Membrane …

The apparent ionization constants (p s K a ) of 25 molecules, based on 431 separate
potentiometric titrations, were determined in methanol/water mixtures of 15–65 wt% methanol …

In this paper the validation of pK a determination in MDM–water mixtures is presented. The
MDM–water mixture is a new multicomponent cosolvent mixture (consisting of equal volumes …

Partition coefficients in the water–octanol, –cyclohexane, and –dichloromethane systems
were determined as a function of pH for three non-zwitterionic ampholytes (nitrazepam, …

In this paper the pH-equilibrium solubility profiles of six organic drugs are presented. The
equilibrium solubility values were determined using the saturation shake-flask and the Chasing …

A novel potentiometric procedure has recently been described for rapid measurement of
equilibrium aqueous solubility values of organic acids, bases, and ampholytes that form …

This commentary addresses data quality in equilibrium solubility measurement in aqueous
solution. Broadly discussed is the “gold standard” shake-flask (SF) method used to measure …

The acid-base equilibria of several diprotic amphoteric drugs, namely, niflumic acid,
norfloxacin, piroxicam, pyridoxine and 2-methyl-4-oxo-3H-quinazoline-3-acetic acid have been …