(H+, K+)-ATPase inhibiting 2-[(2-pyridylmethyl) sulfinyl] benzimidazoles. 4. A novel series of dimethoxypyridyl-substituted inhibitors with enhanced selectivity. The …

…, H Schaefer, G Rainer, V Figala, K Klemm - Journal of medicinal …, 1992 - ACS Publications
[(Pyridylmethyl) sulfinyl] benzimidazoles 1 (PSBs) are a class of highly potentantisecretory (H+,
K+)-ATPase inhibitors which need to be activated by acid to formtheir active principle, the …

Primary structure differences of human surfactant-associated proteins isolated from normal and proteinosis lung

…, E Hannappel, J Maaßen, B Landis, K Klemm… - … et Biophysica Acta (BBA …, 1992 - Elsevier
The primary structures of human pulmonary surfactant-associated proteins SP-A, SP-B and
SP-C isolated from lung lavage of patients with alveolar proteinosis exhibit significant …

Characterization of the dexniguldipine binding site in the multidrug resistance-related transport protein P-glycoprotein by photoaffinity labeling and mass spectrometry

C Borchers, R Boer, K Klemm, V Figala… - Molecular …, 2002 - ASPET
Human P-glycoprotein (P-gp), an integral membrane transport protein, is responsible for the
efflux of various drugs, including cytostatics from cancer cells leading to multidrug resistance…

(H+-K+)-ATPase inhibiting 2-[(2-pyridylmethyl) sulfinyl] benzimidazoles. 2. The reaction cascade induced by treatment with acids. Formation of 5H-pyrido [1', 2': 4, 5][1 …

…, U Krueger, E Sturm, V Figala, K Klemm… - The Journal of …, 1987 - ACS Publications
The elucidation of the acid catalyzed chemical transformations involved in the inhibition of
the gastric (H+-K+)-ATPase by 2-[(2-pyridylmethyl) sulfinyl] benzimidazoles 1, a new class of …

(H+-K+)-ATPase inhibiting 2-[(2-pyridylmethyl) sulfinyl] benzimidazoles. 1. Their reaction with thiols under acidic conditions. Disulfide containing 2 …

…, J Senn-Bilfinger, V Figala, K Klemm… - The Journal of …, 1987 - ACS Publications
… Ernst Sturm,* Uwe Krüger, Jórg Senn-Bilfinger,Volker Figala, Kurt Klemm, Bernhard Kohl,
Georg Rainer, and Hartmann Schaefer … (13) Figala, V.; Klemm, K.; Kohl, B.; Krüger, U.; …

(H+-K+)-ATPase inhibiting 2-[(2-pyridylmethyl) sulfinyl] benzimidazoles. 3. Evidence for the involvement of a sulfenic acid in their reactions

…, E Sturm, V Figala, K Klemm… - The Journal of …, 1990 - ACS Publications
The (H+-K+)-ATPase inhibiting sulfoxides la, b undergo acid-induced transformationsinto
the cyclicsulfenamides 2a, b via the putative sulfenic acids 4a, b. At high concentrations …

B9209-005, an azido derivative of the chemosensitizer dexniguldipine-HCl, photolabels P-glycoprotein.

C Borchers, WR Ulrich, K Klemm, W Ise, V Gekeler… - Molecular …, 1995 - ASPET
P-glycoprotein is an energy-dependent drug extrusion pump for a variety of anticancer drugs
and is involved in the development of multidrug resistance in cancer. Dexniguldipine-HCl is …

Formamid‐Reaktionen, XIV. Reaktionen von Säureamid‐Acylhalogenid‐Addukten: Darstellung substituierter Amidine und Amidrazone

H Bredereck, R Gompper, K Klemm… - Chemische …, 1959 - Wiley Online Library
Die Struktur des kristallin erhaltenen Dimethylformamid‐Phosphoroxychlorid‐Adduktes wird
erörtert. NN‐Disubstituierte Amide geben mit Phosphoroxychlorid und Aminen NNN′‐…

A unique approach to preventing back pain in the dental office

GJ Books, K Klemm - Work, 2012 - content.iospress.com
Back pain has been reported by a majority of dental practitioners for decades. Efforts to relieve
pain have focused on postural modification, exercise, and equipment designed to facilitate…

Formamid‐Reaktionen, XII. Alkylierungs‐und Acylierungsreaktionen an Formamid: Tris‐formylamino‐methan

…, R Gompper, H Rempfer, K Klemm… - Chemische …, 1959 - Wiley Online Library
Die Einwirkung von Alkylierungsmitteln auf Formamid (2 Moll.) liefert Formamidin. Mit einem
Überschuß von Formamid (5–10 Moll.) entsteht Tris‐formylamino‐methan. Die Verbindung …