The global pandemic of SARS-CoV-2, the causative viral pathogen of COVID-19, has driven
the biomedical community to action—to uncover and develop antiviral interventions. One …

Cancer cells engage in a metabolic program to enhance biosynthesis and support cell
proliferation. The regulatory properties of pyruvate kinase M2 (PKM2) influence altered glucose …

Serine is both a proteinogenic amino acid and the source of one-carbon units essential for
de novo purine and deoxythymidine synthesis. In the canonical pathway of glucose-derived …

Multiple sclerosis involves an aberrant autoimmune response and progressive failure of
remyelination in the central nervous system. Prevention of neural degeneration and subsequent …

Loss of function mutations in Kelch-like ECH Associated Protein 1 (KEAP1), or gain-of-function
mutations in nuclear factor erythroid 2-related factor 2 (NRF2), are common in non-small …

Background Effective transvascular delivery of nanoparticle-based chemotherapeutics across
the blood-brain tumor barrier of malignant gliomas remains a challenge. This is due to our …

Cancer multidrug resistance (MDR) mediated by ATP-binding cassette (ABC) transporters
presents a significant unresolved clinical challenge. One strategy to resolve MDR is to …

We report the discovery and medicinal chemistry optimization of a novel series of pyrazole-based
inhibitors of human lactate dehydrogenase (LDH). Utilization of a quantitative high-…

The National Center for Advancing Translational Sciences (NCATS) has developed an online
open science data portal for its COVID-19 drug repurposing campaign–named OpenData–…

Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key metabolic enzymes that are
mutated in a variety of cancers to confer a gain-of-function activity resulting in the accumulation …