Safe and cost-effective adjuvants are a critical component to enhance the efficacy of subunit
vaccines. Studies have demonstrated that modified natural lipid As derived from …

Shock due to Gram-negative bacterial sepsis is a consequence of acute inflammatory
response to lipopolysaccharide (LPS) or endotoxin released from bacteria. LPS is a major …

Endotoxin, from the outer membrane of Gram-negative bacteria, has been implicated as the
etiological agent of a variety of pathologies ranging from relatively mild (fever) to lethal (…

The total synthesis of palytoxin carboxylic acid and palytoxin amide was achieved from the
fully protected palytoxin carboxylic acid. The fully protected palytoxin carboxylic acid 1 …

Respiratory syncytial virus (RSV) is a leading cause of infant mortality worldwide. Toll-like
receptor 4 (TLR4), a signaling receptor for structurally diverse microbe-associated molecular …

The total synthesis of a fully protected palytoxin carboxylic acid was achieved from eight
building blocks 1, 2, 4, 6, 8, 9, 11, and 13. The C. 22-C. 23 and C. 37-C. 38 bonds were formed …

The synthesis and properties of a series of (2S)-2-0-protected-2-hydroxypropanals, where
theprotecting groups are tert-butyldimethylsilyl (3a), tert-butyldiphenylsilyl (3b), and (…

Purpose The effectiveness of vaccines depends on the age and immunocompetence of the
vaccinee. Conventional non-adjuvanted influenza vaccines are suboptimal in the elderly and …

… Hawkins, Todd A. Blythe, Gloria R. Dubuc,and Andrea L. …

ER-112022 is a novel acyclic synthetic lipid A analog that contains six symmetrically organized
fatty acids on a noncarbohydrate backbone. Chinese hamster ovary (CHO)-K1 fibroblasts …