Nucleotides and nucleosides influence nearly every aspect of physiology and pathophysiology.
Extracellular nucleotides are metabolized through regulated phosphohydrolysis by a …

… (LF Thompson, unpuhlished ohservations). The GPI-anchored protein CD 16 has also heen
found to be removed from the cell surface by proteolytic cleavage (129). Alternatively, the …

Recent studies have reported that adenosine is a significant mediator of regulatory T cell (Treg)
function. Indeed, activation of the adenosine receptor subtypes expressed by a broad …

1.1 Historical Perspective Soon after the invention of the point contact transistor over three
decades ago, several important technological trends were rapidly established. First, a …

Under conditions of limited oxygen availability (hypoxia), multiple cell types release
adenine nucleotides in the form of ATP, ADP, and AMP. Extracellular AMP is metabolized to …

Extracellular adenosine has been widely implicated in adaptive responses to hypoxia. The
generation of extracellular adenosine involves phosphohydrolysis of adenine nucleotide …

Background— Ecto-5′-nucleotidase (CD73)–dependent adenosine generation has been
implicated in tissue protection during acute injury. Once generated, adenosine can activate …

CD73, originally defined as a lymphocyte differentiation antigen, is thought to function as a
cosignaling molecule on T lymphocytes and an adhesion molecule that is required for …

Hypoxia is a well-documented inflammatory stimulus and results in tissue polymorphonuclear
leukocyte (PMN) accumulation. Likewise, increased tissue adenosine levels are …

Purpose Recent reports on medical students' career choices suggest that lifestyle increasingly
influences career decisions. The authors addressed the changing influence of lifestyle …