The effect of thiopurine methyltransferase expression on sensitivity to thiopurine drugs

SA Coulthard, LA Hogarth, M Little, EC Matheson… - Molecular …, 2002 - ASPET
Although the thiopurine drugs 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG) are well
established agents for the treatment of leukemia, controversies remain regarding their main …

Loss of heterozygosity in childhood acute lymphoblastic leukemia detected by genome-wide microarray single nucleotide polymorphism analysis

…, L Bloodworth, NP Bown, MC Case, LA Hogarth… - Cancer research, 2005 - AACR
Loss of heterozygosity (LOH) is detectable in many forms of malignancy, including leukemia,
using techniques such as microsatellite analysis and comparative genomic hybridization. …

Increased BAX expression is associated with an increased risk of relapse in childhood acute lymphocytic leukemia

LA Hogarth, AG Hall - Blood, The Journal of the American …, 1999 - ashpublications.org
Studies in cell lines have indicated that expression of the BCL-2 family of proteins is an
important determinant of chemotherapy-induced apoptosis; however, the level of expression of …

The effect of thiopurine drugs on DNA methylation in relation to TPMT expression

LA Hogarth, CPF Redfern, JM Teodoridis… - Biochemical …, 2008 - Elsevier
The thiopurine drugs 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG) are well-established
agents for the treatment of leukaemia but their main modes of action are controversial. …

The clinical impact of thiopurine methyltransferase polymorphisms on thiopurine treatment

…, EC Matheson, AG Hall, LA Hogarth - … and Nucleic Acids, 2004 - Taylor & Francis
Acute lymphoblastic leukaemia (ALL) is the most common malignancy of childhood. Although
current treatment results in long term survival in over 70% of cases there is evidence that …

[HTML][HTML] p53-independent epigenetic repression of the p21WAF1 gene in T-cell acute lymphoblastic leukemia

C Davies, LA Hogarth, PA Dietrich… - Journal of Biological …, 2011 - ASBMB
The p53 protein is a primary mediator of cellular apoptosis and growth arrest after exposure
to DNA-damaging agents. Previous work has shown that the majority of childhood acute …

Increased Sensitivity to Thiopurines in Methylthioadenosine Phosphorylase–Deleted Cancers

…, I Jakobsen-Falk, AG Hall, GA Taylor, LA Hogarth - Molecular cancer …, 2011 - AACR
The thiopurines, 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG), are used in the treatment
of leukemia. Incorporation of deoxythioguanosine nucleotides (dG s ) into the DNA of …

DHFR and MSH3 co-amplification in childhood acute lymphoblastic leukaemia, in vitro and in vivo

EC Matheson, LA Hogarth, MC Case, JAE Irving… - …, 2007 - academic.oup.com
The MSH3 and dihydrofolate reductase (DHFR) genes, located on chromosome 5, share a
common promoter but are divergently transcribed. Dysregulation of the mismatch repair (MMR…

p21WAF1 modulates drug-induced apoptosis and cell cycle arrest in B-cell precursor acute lymphoblastic leukemia

C Davies, LA Hogarth, KL Mackenzie, AG Hall… - Cell Cycle, 2015 - Taylor & Francis
p21 WAF1 is a well-characterized mediator of cell cycle arrest and may also modulate
chemotherapy-induced cell death. The role of p21 WAF1 in drug-induced cell cycle arrest and …

Spatial localization of a goal: Beacon homing and landmark piloting by rats on a radial maze

LA Hogarth, WA Roberts, S Roberts… - Animal Learning & …, 2000 - Springer
… Experiments 1-5 were reported in a master's thesis submitted by LA Hogarth to the … in
Experimer might reveal evidence of landmark piloting under la: mark conditions that did not reveal …