The analgesic and antipyretic drug acetaminophen (APAP) is bioactivated to the reactive
intermediate N-acetyl-p-benzoquinoneimine, which is scavenged by glutathione (GSH). APAP …

Glutathione (GSH) is an important antioxidant and cofactor for glutathione S-transferase
conjugation. GSH synthesis is catalyzed by glutamate cysteine ligase (GCL), composed of …

The concept of nanomedicine is not new. For instance, some nanocrystals and colloidal
drug molecules are marketed that improve pharmacokinetic characteristics of single-agent …

This study investigated the role of cellular antioxidant defense mechanisms in modulating
the neurotoxicity of domoic acid (DomA), by using cerebellar granule neurons (CGNs) from …

Glutathione (GSH) is the most abundant intracellular thiol and an important regulator of cellular
redox status. Mice that lack the modifier subunit of glutamate cysteine ligase (Gclm), the …

Gene expression profiling is a widely used technique with data from the majority of
published microarray studies being publicly available. These data are being used for meta-analyses …

… There is growing interest in developing long-acting (LA) antiretroviral (… Currently, intramuscular
(IM) LA cabotegravir and LA … Because LA cabotegravir and LA rilpivirine both take several …

Drug-combination nanoparticles (DcNPs) administered subcutaneously represent a potential
long-acting lymphatic-targeting treatment for HIV infection. The DcNP containing lopinavir (…

Objective: The aim of the present study was to determine whether a combination of anti-HIV
drugs–tenofovir (TFV), lopinavir (LPV) and ritonavir (RTV)–in a lipid-stabilized …

… LA cabotegravir or LA rilpivirine in NHP and humans. This could be an advantage for our
DcNP formulation because the long duration of subtherapeutic levels of LA … more traditional LA …