Gi/o-coupled receptors compete for signaling to adenylyl cyclase in SH-SY5Y cells and reduce opioid-mediated cAMP overshoot

ES Levitt, LC Purington, JR Traynor - Molecular pharmacology, 2011 - ASPET
Organization of G protein-coupled receptors and cognate signaling partners at the plasma
membrane has been proposed to occur via multiple mechanisms, including membrane …

Development and in Vitro Characterization of a Novel Bifunctional μ-Agonist/δ-Antagonist Opioid Tetrapeptide

LC Purington, K Sobczyk-Kojiro… - ACS chemical …, 2011 - ACS Publications
The development of tolerance to and dependence on opioid analgesics greatly reduces
their long-term usefulness. Previous studies have demonstrated that co-administration of a μ-…

Pentapeptides displaying μ opioid receptor agonist and δ opioid receptor partial agonist/antagonist properties

LC Purington, ID Pogozheva, JR Traynor… - Journal of medicinal …, 2009 - ACS Publications
Chronic use of μ-opioid agonists has been shown to cause neurochemical adaptations
resulting in tolerance and dependence. While the analgesic effects of these drugs are mediated …

Modulation of opioid receptor ligand affinity and efficacy using active and inactive state receptor models

JP Anand, LC Purington, ID Pogozheva… - Chemical biology & …, 2012 - Wiley Online Library
… The identity of all peptides were determined using ESI-MS performed on an Agilent
Technologies LC/MS system using a 1200 Series LC and 6130 Quadrupole LC/MS (Agilent …

Mixed κ/μ opioid receptor agonists: the 6β-naltrexamines

…, AP Neal, FA Bradbury, LC Purington… - Journal of medicinal …, 2009 - ACS Publications
Ligands from the naltrexamine series have consistently demonstrated agonist activity at κ
opioid receptors (KOR), with varying activity at the μ opioid receptor (MOR). Various 6β-…

department of health and heredity of the National Woman's Christian Temperance Union; died at her home in Dorchester, Boston, October 26.

LC Purington - jamanetwork.com
Marriages Page 1 those who are expected to become well within four or five weeks. It is laid
down that the hospitals of this class should have a capacity of 2 per cent, of the army. THE …

[HTML][HTML] A phase 2 randomized controlled multisite study using omalizumab-facilitated rapid desensitization to test continued vs discontinued dosing in multifood …

S Andorf, N Purington, D Kumar, A Long… - …, 2019 - thelancet.com
Background As there is limited data on the sustainability of desensitization of multifood-oral
immunotherapy (multifood-OIT), we conducted a multisite multifood-OIT study to compare the …

Anti-IgE treatment with oral immunotherapy in multifood allergic participants: a double-blind, randomised, controlled trial

S Andorf, N Purington, WM Block, AJ Long… - The lancet …, 2018 - thelancet.com
Background Despite progress in single food oral immunotherapy, there is little evidence
concerning the safety and efficacy of treating individuals with multiple food (multifood) allergies. …

Nonsuicidal self-injury as a gateway to suicide in young adults

…, J Muehlenkamp, J Eckenrode, A Purington… - Journal of adolescent …, 2013 - Elsevier
PURPOSE: To investigate the extent to which nonsuicidal self-injury (NSSI) contributes to
later suicide thoughts and behaviors (STB) independent of shared risk factors. METHODS: …

[HTML][HTML] Eliciting dose and safety outcomes from a large dataset of standardized multiple food challenges

N Purington, RS Chinthrajah, A Long… - Frontiers in …, 2018 - frontiersin.org
Background: Food allergy prevalence has continued to rise over the past decade. While studies
have reported threshold doses for multiple foods, large-scale multi-food allergen studies …