Nuclear factor-κB and liver carcinogenesis

M Arsura, LG Cavin - Cancer letters, 2005 - Elsevier
Hepatocellular carcinoma (HCC) is the third deadliest and fifth most common human cancer
worldwide. Hepatitis C virus (HCV) and hepatitis B virus (HBV) infections along with alcohol …

Transient activation of NF-κB through a TAK1/IKK kinase pathway by TGF-β1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation

M Arsura, GR Panta, JD Bilyeu, LG Cavin, MA Sovak… - Oncogene, 2003 - nature.com
NF-κB has been implicated in the regulation of apoptosis, a key mechanism of normal and
malignant growth control. Previously, we demonstrated that inhibition of NF-κB activity by TGF-…

ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-κB through a common MEK/extracellular signal-regulated kinase/p90rsk signaling …

GR Panta, S Kaur, LG Cavin, ML Cortés… - … and cellular biology, 2004 - Am Soc Microbiol
We have identified a novel pathway of ataxia telangiectasia mutated (ATM) and DNA-dependent
protein kinase (DNA-PK) signaling that results in nuclear factor κB (NF-κB) activation …

Inhibition of CK2 activity by TGF-β1 promotes IκB-α protein stabilization and apoptosis of immortalized hepatocytes

LG Cavin, R Romieu-Mourez, GR Panta, J Sun… - Hepatology, 2003 - Elsevier
Nuclear factor κB (NF-κB) is an antiapoptotic factor involved in development, regeneration,
and neoplastic progression of the liver. Previously, we have shown that stabilization of …

Transforming growth factor-α inhibits the intrinsic pathway of c-Myc-induced apoptosis through activation of nuclear factor-κB in murine hepatocellular carcinomas

LG Cavin, F Wang, VM Factor, S Kaur… - Molecular cancer …, 2005 - AACR
Nuclear factor-κB (NF-κB) plays an important role during liver neoplastic development
through transcriptional regulation of prosurvival genes, which then counteract the death-inducing …

Regulation of α-fetoprotein by nuclear factor-κB protects hepatocytes from tumor necrosis factor-α cytotoxicity during fetal liver development and hepatic oncogenesis

LG Cavin, M Venkatraman, VM Factor, S Kaur… - Cancer research, 2004 - AACR
Nuclear factor-κB (NF-κB) plays a critical role during fetal liver development and hepatic
oncogenesis. Here, we have assessed whether NF-κB activity is required for murine …

Nuclear-factor-κB (NF-κB) and radical oxygen species play contrary roles in transforming growth factor-β1 (TGF-β1)-induced apoptosis in hepatocellular carcinoma …

F Wang, S Kaur, LG Cavin, M Arsura - Biochemical and biophysical …, 2008 - Elsevier
Nuclear-Factor-κB (NF-κΒ can counteract transforming growth factor-β1 (TGF-β1)-induced
apoptosis in malignant hepatocytes through up-regulation of its downstream genes, such as X-…

Circumvention of nuclear factor κB-induced chemoresistance by cytoplasmic-targeted anthracyclines

JD Bilyeu, GR Panta, LG Cavin, CM Barrett… - Molecular …, 2004 - ASPET
Nuclear factor κB (NF-κB) has been implicated in inducible chemoresistance against
anthracyclines. In an effort to improve the cytotoxicity of anthracyclines while reducing their …

[BOOK][B] Interaction of thymidylate synthase with pyridoxal phosphate, FdUMP and folates

LG Cavin - 1998 - search.proquest.com
… She appreciates her loving mother, Almeta Cavin, for her guidance and support throughout
her tenure in graduate school. The rest of her family is appreciated as well for their support. …

Using webcam interactive technology to implement treatment for severe apraxia: A case example

…, AGJ Stierwalt, M Spence, C Cavin-Root - Journal of Medical …, 2010 - go.gale.com
… We believe that several factors helped LG to be successful with this program. LG clearly had
a … We suspect that the use of treatment guided by principles of motor learning helped LG