The peripheral nervous system has remarkable regenerative capacities in that it can repair a
fully cut nerve. This requires Schwann cells to migrate collectively to guide regrowing axons …

Following damage to peripheral nerves, a remarkable process of clearance and regeneration
takes place. Axons downstream of the injury degenerate, while the nerve is remodeled to …

It is generally accepted that poorly written requirements can result in software with the wrong
ftmctionality. The Goddard Space Flight Center's (GSFC) Software Assurance Technology …

Object-oriented design and development are popular concepts in today’s software development
environment. They are often heralded as the silver bullet for solving software problems. …

The design of precision, preclinical therapeutics from sequence is difficult, but advances in
this area, particularly those focused on rational design, could quickly transform the sequence …

The development of a series of potent and highly selective casein kinase 1δ/ε (CK1δ/ε)
inhibitors is described. Starting from a purine scaffold inhibitor (SR-653234) identified by high …

Identification of specific drivers of human cancer is required to instruct the development of
targeted therapeutics. We demonstrate that CSNK1D is amplified and/or overexpressed in …

Objectives Systemic lupus erythematosus (SLE) is an autoimmune disease with extensive
heterogeneity in disease presentation between patients, which is likely due to an underlying …

Neurofibromatosis type 1 (NF1) patients develop neurofibromas, tumors of Schwann cell
origin, as a result of loss of the Ras-GAP neurofibromin. In normal nerves, Schwann cells are …

Heterotopic gray matter, which previously had been associated with severe congenital
malformations of the brain and developmental delay, was found without these associated …