User profiles for L. M. Nowak

Linda Nowak

Associate Professor, Cornell University
Verified email at cornell.edu
Cited by 8988

Mechanisms of blockade of excitatory amino acid receptor channels

JF MacDonald, LM Nowak - Trends in pharmacological sciences, 1990 - Elsevier
… In the fourth article in our series on excitatory amino acids, John MacDonald and Linda
Nowak analyse the characteristics of these two types of block and describe the hypotheses that …

[PDF][PDF] Mechanism of Modulation of AMPA Receptors by TARPγ8

E Carrillo, SA Shaikh, V Berka, LM Nowak… - Biophysical …, 2020 - cell.com
Fast excitatory synaptic transmission in the mammalian central nervous system is mediated
by glutamate activated AMPA receptors (AMPARs). The core GluA subunits of AMPARs in …

GABA and bicuculline actions on mouse spinal cord and cortical neurons in cell culture

LM Nowak, AB Young, RL Macdonald - Brain research, 1982 - Elsevier
The neutral amino acid γ-aminobutyric acid (GABA) produced membrane hyperpolarization
and increased membrane chloride ion conductance of spinal cord (SC) and cortical (CTX) …

Mechanisms of modal activation of GluA3 receptors

K Poon, AH Ahmed, LM Nowak, RE Oswald - Molecular pharmacology, 2011 - ASPET
… Human embryonic kidney 293 cells were stably transfected with the flip form of GluA3-G (SM
Holley and LM Nowak, unpublished observations), and clonal stable cell lines were …

[PDF][PDF] Characterizing single-channel behavior of GluA3 receptors

K Poon, LM Nowak, RE Oswald - Biophysical Journal, 2010 - cell.com
… Human embryonic kidney 293 cells were stably transfected with GluA3i (G) (SM Holley and
LM Nowak, unpublished). The receptor is the flip variant and has a G in the R/G editing site. …

Substance P: ionic basis for depolarizing responses of mouse spinal cord neurons in cell culture

LM Nowak, RL Macdonald - Journal of Neuroscience, 1982 - Soc Neuroscience
Intracellular recording methods were used to investigate the ionic basis for the postsynaptic
actions of substance P (SP) on mouse spinal cord neurons grown in primary dissociated cell …

Bicuculline: A convulsant with synaptic and nonsynapticactions

EJ Heyer, LM Nowak, RL Macdonald - Neurology, 1981 - AAN Enterprises
The convulsant bicuculline (BICUC) had both synaptic and nonsynaptic actions on mouse
spinal cord neurons in primary dissociated cell culture. BICUC antagonized postsynaptic …

Modulation of AMPA receptor gating by the anticonvulsant drug, perampanel

…, CP Ptak, RE Oswald, LM Nowak - ACS Medicinal …, 2018 - ACS Publications
Postsynaptic AMPA/glutamate receptors, essential for neuronal excitability, are important
targets for anticonvulsant therapy. This single channel study of the selective noncompetitive …

Gating reaction mechanism of neuronal NMDA receptors

…, TP Smith, NM Graziane, LM Nowak… - Journal of …, 2012 - journals.physiology.org
The activation mechanisms of recombinant N-methyl-d-aspartate receptors (NRs) have
been established in sufficient detail to account for their single channel and macroscopic …

Membrane depolarization and prolongation of calcium-dependent action potentials of mouse neurons in cell culture by two convulsants: bicuculline and penicillin

EJ Heyer, LM Nowak, RL Macdonald - Brain research, 1982 - Elsevier
The convulsant compounds bicuculline (BICUC) and penicillin (PCN) are antagonists of
GABA-mediated synaptic inhibition. In addition, we have shown that BICUC and PCN produced …