In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise
to generate mutations in virtually every protein-coding gene of the mouse genome in a …

We demonstrate that alpha-ketoacids reduce and, in some instances, abrogate menadione-induced
DNA damage and cytotoxicity in the human breast cancer cell line, MCF7. We …

Menadione (MD; 2-methyl-1,4-naphthoquinone), a redox cycling quinone was shown to
induce single (ss)- and double (ds)-strand DNA breaks in human MCF-7 cells. This DNA …

… LM NUTTER et al. … LM NUTTER et al … Nutter LM. Grill SP and Cheng YC, The sources of
thymidine nucleotides for virus DNA synthesis in herpes simplex virus type 2-infected cells. J Biol …

The o-quinone forms of 2, 3-and 3, 4-catechol estrogens have been implicated in the
carcinogenicity of these hormones. The concomitant production of reactive oxygen species during …

… LM (42). It was of central interest in the present study to … LM culture media for in this manner
revealed that estradiol at … inappropriate decorresponding to 25 ~ LM TNQ. In accordance with …

… Nutter LM). This amount of drug still remaining within the cells may be enough to effect
DNA breakage. The latter may account for the fact that repair of the ss and ds DNA breaks was …

In mammalian cells, the synthesis of DNA requires a continuous supply of deoxyribonucleoside
triphosphates (dNTPs). The formation of dNTPs can be either through the'de novo'…

… We also attempted to grow McA-RH7777 cells in RPMI; however, these cells did not survive
for long in RPMI (EO Ngo and LM Nutter, unpublished results). The generality of the PNPO-…

Phorbol esters and n-butyrate (SB) together could induce Epstein-Barr virus (EBV) DNA
polymerase and DNase activities in Raji cells (virus nonproducer). Neither 12-O-…