Clinical studies suggest a link between type 2 diabetes mellitus (T2DM) and insulin resistance
(IR) and cognitive dysfunction, but there are significant gaps in our knowledge of the …

The family of facilitative glucose transporter (GLUT) proteins is responsible for the entry of
glucose into cells throughout the periphery and the brain. The expression, regulation and …

The adrenal gland releases mineralocorticoids (MCs) and glucocorticoids (GCs) in response
to a variety of stimuli, including stress. Once released, these adrenal steroids mediate a …

Estrogen may mediate some of its effects on hippocampal function through the alpha isoform
of the estrogen receptor (ERα). By light microscopy, ERα‐immunoreactivity (‐I) is found in …

The genetically obese Zucker rat is a widely investigated model of pathological changes
associated with type 2 diabetes. To assess cognitive function, obese and lean Zucker rats were …

Depressive illness is associated with changes in amygdalar volume, and stressful life events
are known to precipitate depressive episodes in this patient population. Stress affects …

Insulin receptors (IRs) are expressed in discrete neuronal populations in the central nervous
system, including the hippocampus. To elucidate the functional role of hippocampal IRs …

In the central nervous system (CNS) insulin mediates a variety of effects including feeding,
metabolism and cognition. The cognitive enhancing effects of insulin are proposed to be …

… A detailed study testing this hypothesis was conducted recently by Reagan and co-workers
111 who have explored the regulation of GLT-1 under conditions that produce hippocampal …

The prevalence of obesity has rapidly escalated and now represents a major public health
concern. Although genetic associations with obesity and related metabolic disorders such as …