Certain solid tumors metastasize to bone and cause osteolysis and abnormal new bone
formation. The respective phenotypes of dysregulated bone destruction and bone formation …

Peroxisome proliferator-activated receptor γ (PPARγ) is a clinically validated target for treatment
of insulin resistance. PPARγ activation by full agonists such as thiazolidinediones has …

… As we have previously reported that APP-695 transgenic mice display no histopathology (Higgins
et ai., 1993), this indirectly supports a link between histopathology and the learning …

The cytokine transforming growth factor (TGF)-β, by virtue of its immunosuppressive and
promigratory properties, has become a major target for the experimental treatment of human …

The beta-amyloid precursor protein (beta-APP), from which the beta-A4 peptide is derived,
is considered to be central to the pathogenesis of Alzheimer disease (AD). Transgenic mice …

Field tests of corn co-expressing two new delta-endotoxins from Bacillus thuringiensis (Bt)
have demonstrated protection from root damage by western corn rootworm (Diabrotica …

MDS is characterized by ineffective hematopoiesis that leads to peripheral cytopenias.
Development of effective treatments has been impeded by limited insight into pathogenic …

β-amyloid (Aβ), derived form the β-amyloid precursor protein (APP), is important for the
pathogenesis of Alzheimer's disease (AD), which is characterized by progressive decline of …

Memory impairment progressing to dementia is the main clinical symptom of Alzheimer's
disease (AD). AD is characterized histologically by the presence of β-amyloid (Aβ) plaques and …

Transforming growth factor β (TGFβ) is a pleiotropic factor that regulates cell proliferation,
angiogenesis, metastasis, and immune suppression. Dysregulation of the TGFβ pathway in …