Brain neuronal nicotinic receptors as new targets for drug discovery

C Gotti, L Riganti, S Vailati… - Current pharmaceutical …, 2006 - ingentaconnect.com
Neuronal nicotinic receptors (nAChRs) are a heterogeneous family of ion channels
differently expressed in the nervous system where, by responding to the endogenous …

Acid sphingomyelinase activity triggers microparticle release from glial cells

…, C Perrotta, L Novellino, M Francolini, L Riganti… - The EMBO …, 2009 - embopress.org
We have earlier shown that microglia, the immune cells of the CNS, release microparticles
from cell plasma membrane after ATP stimulation. These vesicles contain and release IL‐1β, …

Myeloid microvesicles are a marker and therapeutic target for neuroinflammation

…, A Bergami, L Novellino, F Ruffini, L Riganti… - Annals of …, 2012 - Wiley Online Library
Objective: Microvesicles (MVs) have been indicated as important mediators of intercellular
communication and are emerging as new biomarkers of tissue damage. Our previous data …

Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism

F Antonucci, E Turola, L Riganti, M Caleo… - The EMBO …, 2012 - embopress.org
Microvesicles (MVs) released into the brain microenvironment are emerging as a novel way
of cell‐to‐cell communication. We have recently shown that microglia, the immune cells of …

Regulation of neuronal nicotinic receptor traffic and expression

A Gaimarri, M Moretti, L Riganti, A Zanardi… - Brain research …, 2007 - Elsevier
Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of cation channels widely
distributed in the brain, whose subunit composition and biophysical properties vary …

Active endocannabinoids are secreted on extracellular membrane vesicles

…, L Riganti, I Prada, F Antonucci, L Cantone… - EMBO …, 2015 - embopress.org
Endocannabinoids primarily influence neuronal synaptic communication within the nervous
system. To exert their function, endocannabinoids need to travel across the intercellular …

[HTML][HTML] TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice

…, A Leuti, M Mattioli, S Marinelli, L Riganti… - Nature …, 2017 - nature.com
… Note that this staining pattern is also present in the deeper layers of the ACC (o) while is
absent in the IPSI hemisphere of 4 W CCI mice (k,l). (INSET) High-power views of cells from the …

[HTML][HTML] Bone marrow mesenchymal stromal cells drive protective M2 microglia polarization after brain trauma

ER Zanier, F Pischiutta, L Riganti, F Marchesi, E Turola… - …, 2014 - Elsevier
… Seven or 35 days after injury, mice were deeply anesthetized with Equitensin (120 μl/mouse
ip) and transcardially perfused with 20 ml of PBS, 0.1 mol/l, pH 7.4, followed by 50 ml of …

Selective nicotinic acetylcholine receptor subunit deficits identified in Alzheimer's disease, Parkinson's disease and dementia with Lewy bodies by …

…, I Bohr, I Ziabreva, S Vailati, R Longhi, L Riganti… - Neurobiology of …, 2006 - Elsevier
Antibodies raised against human α2-6 and β2-4 nicotinic receptor subunits were utilized to
fractionate 3 H-epibatidine binding in human temporal cortex and striatum. The predominant …

TI‐VAMP/VAMP7 is the SNARE of secretory lysosomes contributing to ATP secretion from astrocytes

…, L Riganti, C Frassoni, E Zuccaro, L Danglot… - Biology of the …, 2012 - Wiley Online Library
… (L) Sucrose equilibrium gradient analysis of density distribution of TI-VAMP and cathepsin
B in ADF glioma. Cathepsin B appears as the precursor form of 46 kDa and the mature forms …