The neural bases of tinnitus: lessons from deafness and cochlear implants

…, MHJ Munk, DM Baguley, L Rüttiger - Journal of …, 2020 - Soc Neuroscience
Subjective tinnitus is the conscious perception of sound in the absence of any acoustic
source. The literature suggests various tinnitus mechanisms, most of which invoke changes in …

[HTML][HTML] Advances in the neurobiology of hearing disorders: recent developments regarding the basis of tinnitus and hyperacusis

M Knipper, P Van Dijk, I Nunes, L Rüttiger… - Progress in …, 2013 - Elsevier
The prevalence of hearing problems in the Western world has, due to aging of the population,
doubled over the past 30 years. Thereby, noise-induced hearing loss is an important factor …

[HTML][HTML] Age-related hearing loss pertaining to potassium ion channels in the cochlea and auditory pathway

…, B Vona, H Löwenheim, L Rüttiger… - … -European Journal of …, 2021 - Springer
Age-related hearing loss (ARHL) is the most prevalent sensory deficit in the elderly and
constitutes the third highest risk factor for dementia. Lifetime noise exposure, genetic …

A splice site mutation in the murine Opa1 gene features pathology of autosomal dominant optic atrophy

…, F Schuettauf, U Schraermeyer, HF Wehrl, L Ruttiger… - Brain, 2007 - academic.oup.com
… the typical pattern of two bands (OPA1 L , OPA1 S ) that were not … L and OPA1 S ) of the
Opa1 enu/+ mutant does not differ from that of wild-type littermates. The proportion of OPA1 L is …

Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence

…, T Schmidt, J Hübener, J Boy, L Rüttiger… - Journal of …, 2007 - Soc Neuroscience
… Cells were grown on coverslips coated with 0.01% poly-l-lysine (Sigma-Aldrich), washed
with PBS, and fixed with ice-cold methanol/acetone for 10 min. After washing with PBS, cells …

Tinnitus behavior and hearing function correlate with the reciprocal expression patterns of BDNF and Arg3. 1/arc in auditory neurons following acoustic trauma

J Tan, L Rüttiger, R Panford-Walsh, W Singer… - Neuroscience, 2007 - Elsevier
The molecular changes following sensory trauma and the subsequent response of the CNS
are poorly understood. We focused on finding a molecular tool for monitoring the features of …

Two classes of outer hair cells along the tonotopic axis of the cochlea

J Engel, C Braig, L Rüttiger, S Kuhn, U Zimmermann… - Neuroscience, 2006 - Elsevier
The molecular basis of high versus low frequency hearing loss and the differences in the
sensitivity of outer hair cells depending on their cochlear localization are currently not …

Lack of brain-derived neurotrophic factor hampers inner hair cell synapse physiology, but protects against noise-induced hearing loss

…, B Schick, W Marcotti, L Rüttiger… - Journal of …, 2012 - Soc Neuroscience
The precision of sound information transmitted to the brain depends on the transfer characteristics
of the inner hair cell (IHC) ribbon synapse and its multiple contacting auditory fibers. …

[HTML][HTML] Reduced sound-evoked and resting-state BOLD fMRI connectivity in tinnitus

…, M Walter, J Thiericke, C Braun, D Zelle, L Rüttiger… - NeuroImage: Clinical, 2018 - Elsevier
… In the volunteer group, the primary and secondary AC regions were positively connected
to BA9D-L, while the auditory nuclei, such as the CN, SOC, and MGB, were negatively …

[HTML][HTML] Lower ototoxicity and absence of hidden hearing loss point to gentamicin C1a and apramycin as promising antibiotics for clinical use

…, M Fernández-Martínez, M Müller, L Rüttiger… - Scientific reports, 2019 - nature.com
… Antimicrobial agents were tested in the range of 64 mg/L to 0.5 mg/L. After bacterial
inoculation, the plates were incubated in air at 35 C for 20 h. The MICs were read visually as the …