Transporters at CNS barrier sites: obstacles or opportunities for drug delivery?
L Sanchez-Covarrubias, LM Slosky… - Current …, 2014 - ingentaconnect.com
The blood-brain barrier (BBB) and blood-cerebrospinal fluid (BCSF) barriers are critical
determinants of CNS homeostasis. Additionally, the BBB and BCSF barriers are formidable …
determinants of CNS homeostasis. Additionally, the BBB and BCSF barriers are formidable …
Transforming growth factor-β signaling alters substrate permeability and tight junction protein expression at the blood-brain barrier during inflammatory pain
…, L Sanchez-Covarrubias… - Journal of Cerebral …, 2009 - journals.sagepub.com
Our laboratory has shown that peripheral inflammatory pain induced by λ-carrageenan (CIP)
can increase blood-brain barrier (BBB) permeability and alter tight junction (TJ) protein …
can increase blood-brain barrier (BBB) permeability and alter tight junction (TJ) protein …
Hypoxia/reoxygenation stress signals an increase in organic anion transporting polypeptide 1a4 (Oatp1a4) at the blood–brain barrier: relevance to CNS drug delivery
BJ Thompson, L Sanchez-Covarrubias… - Journal of Cerebral …, 2014 - journals.sagepub.com
Cerebral hypoxia and subsequent reoxygenation stress (H/R) is a component of several
diseases. One approach that may enable neural tissue rescue after H/R is central nervous …
diseases. One approach that may enable neural tissue rescue after H/R is central nervous …
P‐glycoprotein trafficking at the blood–brain barrier altered by peripheral inflammatory hyperalgesia
…, WD Staatz, L Sanchez‐Covarrubias… - Journal of …, 2012 - Wiley Online Library
J. Neurochem. (2012) 122, 962–975. Abstract P‐glycoprotein (ABCB1/MDR1, EC 3.6.3.44),
the major efflux transporter at the blood–brain barrier (BBB), is a formidable obstacle to CNS …
the major efflux transporter at the blood–brain barrier (BBB), is a formidable obstacle to CNS …
Acetaminophen modulates P-glycoprotein functional expression at the blood-brain barrier by a constitutive androstane receptor–dependent mechanism
LM Slosky, BJ Thompson, L Sanchez-Covarrubias… - Molecular …, 2013 - ASPET
Effective pharmacologic treatment of pain with opioids requires that these drugs attain
efficacious concentrations in the central nervous system (CNS). A primary determinant of CNS …
efficacious concentrations in the central nervous system (CNS). A primary determinant of CNS …
[HTML][HTML] P-glycoprotein modulates morphine uptake into the CNS: a role for the non-steroidal anti-inflammatory drug diclofenac
L Sanchez-Covarrubias, LM Slosky, BJ Thompson… - PloS one, 2014 - journals.plos.org
Our laboratory has previously demonstrated that peripheral inflammatory pain (PIP), induced
by subcutaneous plantar injection of λ-carrageenan, results in increased expression and …
by subcutaneous plantar injection of λ-carrageenan, results in increased expression and …
Tempol modulates changes in xenobiotic permeability and occludin oligomeric assemblies at the blood-brain barrier during inflammatory pain
…, G McCaffrey, L Sanchez-Covarrubias… - American Journal …, 2012 - journals.physiology.org
Our laboratory has shown that λ-carrageenan-induced peripheral inflammatory pain (CIP)
can alter tight junction (TJ) protein expression and/or assembly leading to changes in blood-…
can alter tight junction (TJ) protein expression and/or assembly leading to changes in blood-…
[HTML][HTML] Digitized HIV/AIDS treatment adherence interventions: a review of recent SMS/texting mobile health applications and implications for theory and practice
LM Duthely, AP Sanchez-Covarrubias - Frontiers in communication, 2020 - frontiersin.org
Background: Mobile health technologies (mHealth) are efficacious along the continuum of
HIV/AIDS—from prevention of HIV transmission to those at the highest risk of acquiring …
HIV/AIDS—from prevention of HIV transmission to those at the highest risk of acquiring …
The vaginal microbiome is associated with endometrial cancer grade and histology
…, M Taub, LV Dodds, AP Sanchez-Covarrubias… - Cancer research …, 2022 - AACR
The human microbiome has been strongly correlated with disease pathology and outcomes,
yet remains relatively underexplored in patients with malignant endometrial disease. In this …
yet remains relatively underexplored in patients with malignant endometrial disease. In this …
[HTML][HTML] A multilingual, culturally competent mobile health intervention to improve treatment adherence among women living with HIV: protocol for a randomized …
LM Duthely, AP Sanchez-Covarrubias… - JMIR research …, 2020 - researchprotocols.org
Background: Adherence to HIV care is complex, as barriers to care are multidimensional,
particularly for ethnic minority women. Mobile health (mHealth) solutions are supportive in …
particularly for ethnic minority women. Mobile health (mHealth) solutions are supportive in …